Stack M J, Chaplin M J, Aldrich A M, Davis L A
Veterinary Laboratories Agency, Central Veterinary Laboratory, Addlestone, Surrey.
Res Vet Sci. 1998 Mar-Apr;64(2):141-6. doi: 10.1016/s0034-5288(98)90009-1.
The distribution of scrapie-associated fibrils (SAFs) throughout four brain regions, the pituitary gland, along the whole length of the spinal cord and in the sciatic nerve was assessed in 10 sheep terminally affected by scrapie and in four control sheep. Tonsils, retropharyngeal, broncho-mediastinal and mesenteric lymph nodes, the distal ileum, proximal colon and spleen were also examined for fibrils in all 14 sheep. Fibrils were detected in all four brain regions and throughout the length of the spinal cord in nine of the scrapie affected sheep. SAFs were not detectable in any of the sciatic nerve samples tested. In one of the 10 clinically affected sheep only minimal lesions were found by histopathology and fibrils were detected only from the cerebrum and one spinal cord region (taken at the C1 C2 vertebrae). Fibrils were not detected in the tonsils or retropharyngeal lymph nodes but were detected in other non-neural tissues of some of the scrapie-affected sheep. These tissues included pituitary gland, broncho-mediastinal and mesenteric portal lymph nodes, distal ileum, proximal colon and spleen. Fibrils could not be detected in any of the tissues taken from the four control sheep.
在10只终末期患羊瘙痒症的绵羊和4只对照绵羊中，评估了瘙痒病相关纤维（SAFs）在四个脑区、垂体、脊髓全长和坐骨神经中的分布情况。还对所有14只绵羊的扁桃体、咽后、支气管纵隔和肠系膜淋巴结、回肠末端、近端结肠和脾脏进行了纤维检查。在9只患羊瘙痒症的绵羊中，在所有四个脑区和脊髓全长均检测到纤维。在所检测的任何坐骨神经样本中均未检测到SAFs。在10只临床患病绵羊中的一只中，通过组织病理学仅发现了轻微病变，仅在大脑和一个脊髓区域（取自C1 C2椎骨）检测到纤维。在扁桃体或咽后淋巴结中未检测到纤维，但在一些患羊瘙痒症的绵羊的其他非神经组织中检测到了纤维。这些组织包括垂体、支气管纵隔和肠系膜门淋巴结、回肠末端、近端结肠和脾脏。在取自4只对照绵羊的任何组织中均未检测到纤维。
