Gibson P H, Somerville R A, Fraser H, Foster J D, Kimberlin R H
Vet Rec. 1987 Feb 7;120(6):125-7. doi: 10.1136/vr.120.6.125.
Previous research has consistently demonstrated by electron microscopy the presence of scrapie associated fibrils in brain extracts prepared from mice and hamsters with clinical signs of experimental scrapie. In the present study similar fibrils were seen in all the brain extracts prepared from 11 Cheviot or Suffolk sheep with natural or experimental scrapie that had been diagnosed clinically and confirmed neuropathologically. They were not found in the brain extracts of nine sheep that did not have scrapie and which included four that had been injected with infected material but did not develop the disease. The presence of such fibrils can therefore be used as an additional diagnostic criterion for natural scrapie in sheep.
以往的研究通过电子显微镜一直证明，从出现实验性瘙痒病临床症状的小鼠和仓鼠制备的脑提取物中存在瘙痒病相关纤维。在本研究中，从11只患有自然或实验性瘙痒病的切维厄特羊或萨福克羊制备的所有脑提取物中都观察到了类似的纤维，这些羊已经过临床诊断并经神经病理学证实。在9只没有患瘙痒病的羊的脑提取物中未发现这些纤维，其中包括4只注射了感染物质但未发病的羊。因此，这种纤维的存在可用作绵羊自然瘙痒病的一项额外诊断标准。
