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[抗结核药所致多发性神经病。29例患者的运动神经传导研究]

[Polyneuropathy caused by tuberculostatics. Study of motor nerve conduction in 29 patients].

作者信息

Werneck L C

出版信息

Arq Neuropsiquiatr. 1976 Sep;34(3):223-31. doi: 10.1590/s0004-282x1976000300002.

DOI:10.1590/s0004-282x1976000300002
PMID:962634
Abstract

The electroneurographic study in 29 patients, during treatment with isoniazid for pulmonary tuberculosis in 12 months period is reported. The patients age were between 16 and 70 years. During the study period motor nerve conduction velocity was done every two months in the median, ulnar and peroneal nerves. The statistical analysis in a 6 months period, revealed p greater than 0.05 (nonsignificant) at the median and peroneal nerves, in spite of the lowering of the motor nerve conduction in a 12 months period. The same findings were observed with the ulnar nerve, but p less than 0.01 (significant). It was impossible to establish a correlation between the motor nerve conduction velocities and the clinical findings observed in the patients. This paper, in the author's opinion, shows that the nerve motor conduction technique is worthless in the follow up of isoniazid patients.

摘要

报告了对29例患者进行的神经电图研究,这些患者在12个月期间接受异烟肼治疗肺结核。患者年龄在16至70岁之间。在研究期间,每隔两个月对正中神经、尺神经和腓总神经进行运动神经传导速度检测。在6个月期间的统计分析显示,尽管在12个月期间运动神经传导速度有所降低,但正中神经和腓总神经的p值大于0.05(无统计学意义)。尺神经也观察到了相同的结果,但p值小于0.01(有统计学意义)。无法在患者的运动神经传导速度与临床观察结果之间建立相关性。作者认为,本文表明神经运动传导技术在异烟肼治疗患者的随访中毫无价值。

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