Thatcher R W, Biver C, McAlaster R, Camacho M, Salazar A
Bay Pines VA Medical Center, Florida 33744, USA.
Neuroimage. 1998 May;7(4 Pt 1):352-67. doi: 10.1006/nimg.1998.0330.
Nuclear magnetic resonance of brain water proton (1H) T2 relaxation times and measures of absolute amplitude of EEG were obtained from 19 closed head injured patients. The relationship between EEG and T2 relaxation time differed as a function of both EEG frequency and gray matter versus white matter. White matter T2 relaxation time was positively correlated with increased EEG amplitude in the delta frequency band (0.5-3.5 Hz). In contrast, lengthened gray matter T2 relaxation time was inversely correlated with EEG amplitude in the alpha and beta frequency bands (7-22 Hz). These findings are consistent with clinical EEG studies in which white matter lesions are related to increased EEG delta amplitude and gray matter lesions are related to decreased EEG alpha and beta frequency amplitude. Estimates of the severity of injury were obtained by neuropsychological measurements, in which lengthened T2 relaxation times in both the neocortical gray and white matter were correlated with diminished cognitive function. Decreased EEG beta and alpha amplitude and increased EEG delta amplitude were also correlated with diminished cognitive function. The findings imply a biophysical linkage between the state of protein-lipid structures of the brain as measured by the MRI and the scalp-recorded EEG.
从19名闭合性颅脑损伤患者中获取了脑水质子（1H）T2弛豫时间的核磁共振数据以及脑电图绝对波幅的测量值。脑电图与T2弛豫时间之间的关系因脑电图频率以及灰质与白质的不同而有所差异。白质T2弛豫时间与δ频段（0.5 - 3.5赫兹）脑电图波幅增加呈正相关。相比之下，灰质T2弛豫时间延长与α和β频段（7 - 22赫兹）脑电图波幅呈负相关。这些发现与临床脑电图研究一致，在临床研究中，白质病变与脑电图δ波幅增加有关，灰质病变与脑电图α和β频段波幅降低有关。通过神经心理学测量获得损伤严重程度的估计值，其中新皮质灰质和白质中T2弛豫时间延长与认知功能减退相关。脑电图β波和α波波幅降低以及脑电图δ波波幅增加也与认知功能减退相关。这些发现表明，通过磁共振成像测量的大脑蛋白质 - 脂质结构状态与头皮记录的脑电图之间存在生物物理联系。
