Thatcher R W, Biver C, McAlaster R, Salazar A
VA Medical Center, Research and Development Service, Bay Pines, Florida, USA.
Neuroimage. 1998 Nov;8(4):307-26. doi: 10.1006/nimg.1998.0365.
Using conventional MRI procedures, nuclear magnetic resonance (NMR) of brain water proton (1H) T2 relaxation times and EEG coherence were obtained from two independent groups of closed head injured (CHI) patients and a group of normal control subjects. Statistically significant intercorrelations were observed between 1H T2 relaxation times of the cortical gray and white matter and EEG coherence. The analyses showed that lengthened 1H T2 relaxation times of the cortical gray and white matter were related to: (1) decreased EEG coherence between short interelectrode distances (e.g., 7 cm) and increased EEG coherence between long interelectrode distances (e.g., 28 cm), (2) differences in EEG frequency in which T2 relaxation time was most strongly related to the gray matter in the delta and theta frequencies in CHI patients, and (3) increased T2 relaxation time and decreased short-distance EEG coherence were related to reduced cognitive function. The results were interpreted in terms of reduced integrity of protein/lipid neural membranes and the efficiency and effectiveness of short- and long-distance neural synchronization following traumatic brain injury.
通过传统的磁共振成像程序，从两组独立的闭合性颅脑损伤（CHI）患者和一组正常对照受试者中获取了脑水质子（1H）T2弛豫时间的核磁共振（NMR）和脑电图相干性数据。在皮质灰质和白质的1H T2弛豫时间与脑电图相干性之间观察到了具有统计学意义的相互关联。分析表明，皮质灰质和白质的1H T2弛豫时间延长与以下因素有关：（1）短电极间距（如7厘米）之间的脑电图相干性降低，长电极间距（如28厘米）之间的脑电图相干性增加；（2）脑电图频率的差异，其中T2弛豫时间在CHI患者的δ波和θ波频率中与灰质的相关性最强；（3）T2弛豫时间增加和短距离脑电图相干性降低与认知功能下降有关。这些结果被解释为创伤性脑损伤后蛋白质/脂质神经膜的完整性降低以及短距离和长距离神经同步的效率和有效性降低。
