Halme S, von Hertzen L, Bloigu A, Kaprio J, Koskenvuo M, Leinonen M, Saikku P, Surcel H M
National Public Health Institute, Department of Medical Microbiology, University of Oulu, Finland.
Scand J Immunol. 1998 May;47(5):517-20. doi: 10.1046/j.1365-3083.1998.00332.x.
In this work, cell-mediated immunity to Chlamydia pneumoniae was studied in 157 healthy individuals using lymphoproliferative assay and serum antibodies were analysed by microimmunofluorescence techniques. The C. pneumoniae-specific IgG antibodies were elevated more frequently and the geometric mean titres for IgG (67.5 versus 44.1; P = 0.05) and IgA (14.9 versus 11.3; P = 0.025) antibodies were significantly higher in males than in females. However, no gender-dependent differences were observed in cellular reactivity to C. pneumoniae, since the median cellular responses were similar (stimulation indices 7.5) in men and women. Although the cell-mediated and humoral responses to C. pneumoniae did not correlate clearly, elevated IgG antibodies were associated with slightly higher lymphocyte proliferation in comparison to all subjects (15.5 versus 7.5) and significantly stronger in comparison to those with persistently elevated IgA (> 80) antibodies (15.5 versus 3.5; P = 0.023). Further studies are needed to evaluate a possible role of reduced cellular reactivity in the cause of chronic C. pneumoniae infection.
在这项研究中，我们采用淋巴细胞增殖试验对157名健康个体的肺炎衣原体细胞介导免疫进行了研究，并运用微量免疫荧光技术分析了血清抗体。肺炎衣原体特异性IgG抗体升高的情况更为常见，男性IgG抗体的几何平均滴度（67.5对44.1；P = 0.05）和IgA抗体的几何平均滴度（14.9对11.3；P = 0.025）显著高于女性。然而，在肺炎衣原体细胞反应性方面未观察到性别差异，因为男性和女性的细胞反应中位数相似（刺激指数均为7.5）。尽管肺炎衣原体的细胞介导反应和体液反应没有明显的相关性，但与所有受试者相比，IgG抗体升高与淋巴细胞增殖略有增加相关（15.5对7.5），与IgA抗体持续升高（> 80）的受试者相比则显著更强（15.5对3.5；P = 0.023）。需要进一步研究以评估细胞反应性降低在慢性肺炎衣原体感染病因中的可能作用。
