Evers J L, Slaats P, Land J A, Dumoulin J C, Dunselman G A
Department of Obstetrics and Gynecology, Academisch Ziekenhuis Maastricht and The University of Maastricht, The Netherlands.
Fertil Steril. 1998 Jun;69(6):1010-4. doi: 10.1016/s0015-0282(98)00080-6.
To evaluate whether the predictive ability of a normal FSH level on cycle day 3 can be enhanced by levels of estradiol-17beta (E2) on cycle day 3.
Prospective cohort study.
University hospital-based, tertiary care infertility center.
PATIENT(S): Two hundred thirty-one consecutively seen patients who attended the center for their first IVF attempt.
INTERVENTION(S): Blood samples were collected on day 3 of the cycle preceding IVF; IVF was performed in all patients.
MAIN OUTCOME MEASURE(S): Patient's age, number of ampules of hMG, cancellation rate, number of oocytes, fertilization rate, and clinical pregnancy rate.
RESULT(S): In patients with elevated FSH levels on cycle day 3, a low oocyte yield was achieved (7 versus 11) and a high number of ampules of hMG was necessary (56 versus 33). Their cancellation rate was high (67% versus 16%). In patients with normal basal FSH levels, high E2 levels predicted a high cancellation rate (56%, versus 13% in patients with low E2 levels) and a low oocyte yield (9, versus 11 in patients with low E2 levels). Patients with both normal FSH levels and low E2 levels on cycle day 3 fared best.
CONCLUSION(S): The basal E2 level on cycle day 3 is a useful prognosticator of response to stimulation in IVF patients with normal basal FSH levels.
评估在月经周期第3天正常促卵泡激素（FSH）水平的预测能力是否能通过第3天的雌二醇-17β（E2）水平得到增强。
前瞻性队列研究。
大学附属医院的三级护理不孕不育中心。
连续231例首次到该中心尝试体外受精（IVF）的患者。
在IVF前一个周期的第3天采集血样；所有患者均接受IVF治疗。
患者年龄、人绝经期促性腺激素（hMG）用量、取消率、卵母细胞数量、受精率及临床妊娠率。
月经周期第3天FSH水平升高的患者，卵母细胞产量低（7个对11个），需要大量hMG（56支对33支），取消率高（67%对16%）。基础FSH水平正常的患者中，E2水平高预示取消率高（56%，而E2水平低的患者为13%）和卵母细胞产量低（9个，而E2水平低的患者为11个）。月经周期第3天FSH水平和E2水平均正常的患者情况最佳。
月经周期第3天的基础E2水平是基础FSH水平正常的IVF患者刺激反应的有用预后指标。
