Jones K, Johnson K A, Becker J A, Spiers P A, Albert M S, Holman B L
Department of Psychiatry, Massachusetts General Hospital, Boston, USA.
J Nucl Med. 1998 Jun;39(6):965-73.
The main objective of this study was to characterize changes in brain perfusion associated with normal aging and gender.
Perfusion SPECT images using 99mTc-hexamethyl propyleneamine oxime (HMPAO) were obtained from 152 healthy subjects (67 men, 85 women) aged 50-92 yr. An automated method was developed to objectively assess image data from a large number of brain regions. Image data were reduced with singular value decomposition (SVD), which produced 20 eigenvectors capturing 97.05% of the total information content of 4320 regions from each subject. Subjects were scored individually on each vector.
Multivariate analyses demonstrated that there were no significant differences in whole-brain HMPAO uptake with age, but age-related regional declines were seen in lateral ventricular regions. Women had higher HMPAO uptake than men in estimates of global perfusion and regional perfusion in the midcingulate/corpus callosum, inferior temporal and inferior parietal areas.
These discriminations demonstrate that singular value deomposition of SPECT data may be used to assess differences in perfusion patterns between groups of subjects. They replicate several previous findings, both with respect to age-related changes in perfusion and with respect to gender differences. In addition, they identify a previously unreported gender difference in biparietal regions.
本研究的主要目的是描述与正常衰老和性别相关的脑灌注变化。
使用99m锝-六甲基丙烯胺肟（HMPAO）获得了152名年龄在50 - 92岁的健康受试者（67名男性，85名女性）的灌注单光子发射计算机断层扫描（SPECT）图像。开发了一种自动方法来客观评估来自大量脑区的图像数据。图像数据通过奇异值分解（SVD）进行降维，该方法产生20个特征向量，捕获了每个受试者4320个区域总信息含量的97.05%。对每个受试者在每个向量上进行单独评分。
多变量分析表明，全脑HMPAO摄取量随年龄无显著差异，但在侧脑室区域可见与年龄相关的局部下降。在扣带回中部/胼胝体、颞下回和顶下叶区域的整体灌注和局部灌注估计中，女性的HMPAO摄取量高于男性。
这些差异表明，SPECT数据的奇异值分解可用于评估不同受试者组之间灌注模式的差异。它们重复了先前的一些发现，包括与灌注的年龄相关变化以及性别差异方面的发现。此外，它们还识别出了顶叶区域先前未报道的性别差异。
