Ones U, Güler N, Somer A, Salman N, Yalçin I
Department of Paediatric Infectious Diseases, Clinical Immunology and Allergy, Istanbul Medical Faculty, Istanbul University, Turkey.
Acta Paediatr. 1998 Apr;87(4):368-70.
This study aimed to investigate the prevalence of IgG subclass deficiency in wheezy children aged <3 y. Serum levels of IgA, IgE and IgG subclasses were measured in 310 children with recurrent wheezing and in 100 healthy controls. IgG3 levels were below the normal lower limit in 123 (39.6%) patients. This finding may reflect delayed maturation of the immune system, predisposing young children <3 y of age to wheezing.
本研究旨在调查3岁以下喘息儿童中IgG亚类缺陷的患病率。对310例反复喘息儿童和100例健康对照者测定了血清IgA、IgE和IgG亚类水平。123例（39.6%）患者的IgG3水平低于正常下限。这一发现可能反映了免疫系统成熟延迟，使3岁以下幼儿易患喘息。
