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1
PRAK, a novel protein kinase regulated by the p38 MAP kinase.PRAK，一种由p38丝裂原活化蛋白激酶调节的新型蛋白激酶。
EMBO J. 1998 Jun 15;17(12):3372-84. doi: 10.1093/emboj/17.12.3372.
2
Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle.平滑肌中通过p38丝裂原活化蛋白激酶和丝裂原活化蛋白激酶激活蛋白激酶对27-kDa热休克蛋白进行磷酸化。
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3
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.丝裂原活化蛋白（MAP）激酶激活的蛋白激酶-3的鉴定，CSBP p38 MAP激酶的一种新底物。
J Biol Chem. 1996 Apr 5;271(14):8488-92. doi: 10.1074/jbc.271.14.8488.
4
Regulation of PRAK subcellular location by p38 MAP kinases.p38丝裂原活化蛋白激酶对PRAK亚细胞定位的调控。
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MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.MNK1是一种新的丝裂原活化蛋白激酶激活的蛋白激酶，通过一种用于鉴定蛋白激酶底物的新型表达筛选方法分离得到。
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6
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Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.丝裂原活化蛋白激酶激活丝氨酸/苏氨酸激酶Mnk1和Mnk2。
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Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells.原代人红细胞中p38丝裂原活化蛋白激酶亚型的分化阶段特异性激活。
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MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.丝裂原活化蛋白激酶相关蛋白激酶5（MAPKAPK5）是一种新型的丝裂原活化蛋白激酶（MAPK）激活的蛋白激酶，是细胞外调节激酶（ERK）和p38激酶的底物。
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本文引用的文献

1
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.p38 丝裂原活化蛋白激酶家族第四个成员 p38δ 的结构与功能特性研究
J Biol Chem. 1997 Nov 28;272(48):30122-8. doi: 10.1074/jbc.272.48.30122.
2
A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression.p38丝裂原活化蛋白激酶通路在心肌细胞生长、肌节组织形成及心脏特异性基因表达中的作用。
J Cell Biol. 1997 Oct 6;139(1):115-27. doi: 10.1083/jcb.139.1.115.
3
MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.MKK7是一种与hemipterous功能相关的应激激活的丝裂原活化蛋白激酶激酶。
J Biol Chem. 1997 Oct 3;272(40):24994-8. doi: 10.1074/jbc.272.40.24994.
4
Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38.鉴定c-Jun氨基末端蛋白激酶（JNK）激活激酶2为JNK而非p38的激活剂。
J Biol Chem. 1997 Oct 3;272(40):24751-4. doi: 10.1074/jbc.272.40.24751.
5
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.一种新型p38丝裂原活化蛋白激酶的分子克隆与鉴定
J Biol Chem. 1997 Sep 19;272(38):23668-74. doi: 10.1074/jbc.272.38.23668.
6
Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells.应激激活蛋白激酶级联反应参与嗜铬细胞中酪氨酸羟化酶的激活。
Eur J Biochem. 1997 Aug 1;247(3):1180-9. doi: 10.1111/j.1432-1033.1997.01180.x.
7
Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney.缺血/再灌注心脏和肾脏中应激激酶激活的组织特异性模式。
J Biol Chem. 1997 Aug 8;272(32):19943-50. doi: 10.1074/jbc.272.32.19943.
8
Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3.促红细胞生成素和白细胞介素-3对p38丝裂原活化蛋白激酶途径的激活作用。
Blood. 1997 Aug 1;90(3):929-34.
9
Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells.p38丝裂原活化蛋白激酶在谷氨酸诱导的大鼠小脑颗粒细胞凋亡中的激活与参与
J Biol Chem. 1997 Jul 25;272(30):18518-21. doi: 10.1074/jbc.272.30.18518.
10
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.细胞因子和细胞应激对新型应激激活蛋白激酶SAPK4的激活由SKK3（MKK6）介导；其底物特异性与其他SAP激酶的比较。
EMBO J. 1997 Jun 16;16(12):3563-71. doi: 10.1093/emboj/16.12.3563.

PRAK，一种由p38丝裂原活化蛋白激酶调节的新型蛋白激酶。

PRAK, a novel protein kinase regulated by the p38 MAP kinase.

作者信息

New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood L J, Kato Y, Parry G C, Han J

机构信息

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

出版信息

EMBO J. 1998 Jun 15;17(12):3372-84. doi: 10.1093/emboj/17.12.3372.

DOI:10.1093/emboj/17.12.3372
PMID:9628874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1170675/
Abstract

We have identified and cloned a novel serine/ threonine kinase, p38-regulated/activated protein kinase (PRAK). PRAK is a 471 amino acid protein with 20-30% sequence identity to the known MAP kinase-regulated protein kinases RSK1/2/3, MNK1/2 and MAPKAP-K2/3. PRAK was found to be expressed in all human tissues and cell lines examined. In HeLa cells, PRAK was activated in response to cellular stress and proinflammatory cytokines. PRAK activity was regulated by p38alpha and p38beta both in vitro and in vivo and Thr182 was shown to be the regulatory phosphorylation site. Activated PRAK in turn phosphorylated small heat shock protein 27 (HSP27) at the physiologically relevant sites. An in-gel kinase assay demonstrated that PRAK is a major stress-activated kinase that can phosphorylate small heat shock protein, suggesting a potential role for PRAK in mediating stress-induced HSP27 phosphorylation in vivo.

摘要

我们已经鉴定并克隆了一种新型丝氨酸/苏氨酸激酶，即p38调节/激活蛋白激酶（PRAK）。PRAK是一种由471个氨基酸组成的蛋白质，与已知的丝裂原活化蛋白激酶（MAP激酶）调节的蛋白激酶RSK1/2/3、MNK1/2和MAPKAP-K2/3具有20%-30%的序列同一性。研究发现PRAK在所检测的所有人类组织和细胞系中均有表达。在HeLa细胞中，PRAK会响应细胞应激和促炎细胞因子而被激活。在体外和体内，PRAK的活性均受p38α和p38β调节，并且Thr182被证明是调节性磷酸化位点。激活的PRAK继而在生理相关位点磷酸化小热休克蛋白27（HSP27）。凝胶内激酶分析表明，PRAK是一种主要的应激激活激酶，能够磷酸化小热休克蛋白，这表明PRAK在体内介导应激诱导的HSP27磷酸化过程中可能发挥作用。