动物肝脏色氨酸吡咯酶：对色氨酸毒性敏感的物种中无脱辅基酶及激素诱导机制。
Animal liver tryptophan pyrrolases: Absence of apoenzyme and of hormonal induction mechanism from species sensitive to tryptophan toxicity.
作者信息
Badawy A A, Evans M
出版信息
Biochem J. 1976 Jul 15;158(1):79-88. doi: 10.1042/bj1580079.
Abstract
- Liver tryptophan pyrrolase exists as holoenzyme and apoenzyme in rat, mouse, pig, turkey, chicken and possibly man. 2. The apoenzyme is absent from cat, frog, gerbil, guinea pig, hamster, ox, sheep and rabbit. 3. The hormonal mechanism of induction of the pyrrolase is absent from species lacking the apoenzyme. 4. The concentrations of tryptophan in livers and sera of these species are lower than in species possessing the apoenzyme. 5. Species lacking the apoenzyme or the hormonal induction mechanism have a deficient kynurenine pathway and are sensitive to the toxicity of tryptophan. 6. It is suggested that these species are not suitable as models for studying human tryptophan metabolism. 7. The possible significance of these findings in relation to veterinary and human neonatal care is discussed.
摘要
- 肝脏色氨酸吡咯酶在大鼠、小鼠、猪、火鸡、鸡以及可能在人类中以全酶和脱辅基酶的形式存在。2. 猫、青蛙、沙鼠、豚鼠、仓鼠、牛、绵羊和兔子体内不存在脱辅基酶。3. 缺乏脱辅基酶的物种不存在诱导吡咯酶的激素机制。4. 这些物种肝脏和血清中的色氨酸浓度低于拥有脱辅基酶的物种。5. 缺乏脱辅基酶或激素诱导机制的物种犬尿氨酸途径存在缺陷，并且对色氨酸的毒性敏感。6. 有人认为这些物种不适宜作为研究人类色氨酸代谢的模型。7. 讨论了这些发现与兽医和人类新生儿护理相关的可能意义。
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