Persson-Moschos M, Alfthan G, Akesson B
Department of Applied Nutrition and Food Chemistry, Center for Chemistry and Chemical Engineering, University of Lund, Sweden.
Eur J Clin Nutr. 1998 May;52(5):363-7. doi: 10.1038/sj.ejcn.1600565.
To assess changes in selenoprotein P levels in plasma from subjects who had received oral supplements of different selenium forms.
The same study group participated in two similar selenium supplementation trials, Trial I in 1981 (Levander et al, 1983) and Trial II in 1987 (Alfthan et al, 1991). During Trial II the mean baseline intake of selenium in Finland was higher compared to that during Trial I (100 and 40 microg/d, respectively), due to a nationwide supplementation of fertilisers which started in 1985.
Fifty healthy Finnish men, 36-60 y old.
The study group received daily placebo or oral supplements consisting of 200 microg selenium as selenium-enriched yeast, sodium selenate or selenium-enriched wheat (Trial I) or selenium-enriched yeast, sodium selenate or sodium selenite (Trial II). The duration of supplementation periods was 11 (Trial I) and 16 (Trial II) weeks.
In Trial I the mean plasma selenoprotein P values in all the supplemented groups increased significantly, approaching a plateau at 2 weeks and reaching maxima at 4 weeks (mean increase 34%, P < 0.05). In Trial II the mean selenoprotein P levels of the supplemented groups were not significantly different from each other or from the placebo group at the start or at any time point of the supplementation period.
At a low selenium status the selenoprotein P levels increased in a similar fashion after supplementation with different forms of selenium, but at a high selenium status no significant effects of supplementation with the same amount of selenium were observed. No differences in selenoprotein P levels were observed for inorganic and organic selenium supplements.
评估接受不同硒形式口服补充剂的受试者血浆中硒蛋白P水平的变化。
同一研究组参与了两项相似的硒补充试验，1981年的试验I（莱万德等人，1983年）和1987年的试验II（阿尔夫坦等人，1991年）。在试验II期间，芬兰的硒平均基线摄入量高于试验I期间（分别为100和40微克/天），这是由于1985年开始的全国性肥料补充。
50名健康的芬兰男性，年龄在36至60岁之间。
研究组每日接受安慰剂或口服补充剂，补充剂包含200微克硒，形式为富硒酵母、硒酸钠或富硒小麦（试验I）或富硒酵母、硒酸钠或亚硒酸钠（试验II）。补充期的持续时间分别为11周（试验I）和16周（试验II）。
在试验I中，所有补充组的血浆硒蛋白P平均水平均显著升高，在2周时接近平台期，4周时达到最大值（平均升高34%，P<0.05）。在试验II中，补充组的硒蛋白P平均水平在补充期开始时或任何时间点与安慰剂组相比均无显著差异。
在低硒状态下，补充不同形式的硒后，硒蛋白P水平以相似的方式升高，但在高硒状态下，补充相同量的硒未观察到显著效果。无机和有机硒补充剂在硒蛋白P水平上未观察到差异。
