组蛋白构象的预测。
Prediction of the conformation of the histones.
作者信息
Fasman G D, Chou P Y, Adler A J
出版信息
Biophys J. 1976 Oct;16(10):1201-38. doi: 10.1016/S0006-3495(76)85768-2.
Abstract
The secondary structures of the histones, H1, H2A, H2B, H3, and H4 have been predicted utilizing the predictive scheme of Chou and Fasman (Biochemistry 13:211, 222[1974]) and a new set of conformational parameters based on the X-ray data of 29 protein structures. The alpha-helical, beta-sheet, reverse beta-turns, and random coil regions of these proteins are carefully delineated. Structures are specified which are most probably under various environmental conditions, i.e., for changes in ionic strength, association between histones and in association with DNA. Potential conformational changes within these histones are also predicted.
摘要
利用周和法斯曼的预测方案（《生物化学》13:211, 222[1974]）以及基于29种蛋白质结构的X射线数据的一组新的构象参数，预测了组蛋白H1、H2A、H2B、H3和H4的二级结构。仔细描绘了这些蛋白质的α螺旋、β折叠、反向β转角和无规卷曲区域。确定了在各种环境条件下最可能出现的结构，即离子强度变化、组蛋白之间的缔合以及与DNA缔合时的结构。还预测了这些组蛋白内潜在的构象变化。
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