肝细胞生长因子可上调上皮细胞对铜绿假单胞菌侵袭和细胞毒性的易感性。
Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor.
作者信息
Fleiszig S M, Vallas V, Jun C H, Mok L, Balkovetz D F, Roth M G, Mostov K E
机构信息
The Morton D. Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California, Berkeley, California, USA.
出版信息
Infect Immun. 1998 Jul;66(7):3443-6. doi: 10.1128/IAI.66.7.3443-3446.1998.
Abstract
Normal cell polarity protects epithelial cells against Pseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered without disrupting tight junctions. The results also showed that cellular susceptibility factors for invasion and cytotoxicity are not the same, although both are localized to the basolateral cell surface in polarized epithelial cells.
摘要
正常细胞极性可保护上皮细胞免受铜绿假单胞菌的侵袭和细胞毒性作用。利用在膜成分分选方面存在选择性缺陷的上皮细胞克隆，并采用肝细胞生长因子预处理，我们发现，在不破坏紧密连接的情况下，对铜绿假单胞菌的极化易感性可发生改变。结果还表明，尽管在极化上皮细胞中，侵袭和细胞毒性的细胞易感因子均定位于基底外侧细胞表面，但二者并不相同。
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本文引用的文献
1
Pseudomonas aeruginosa invasion and cytotoxicity are independent events, both of which involve protein tyrosine kinase activity.铜绿假单胞菌的侵袭和细胞毒性是独立事件，两者均涉及蛋白酪氨酸激酶活性。
Infect Immun. 1998 Apr;66(4):1453-9. doi: 10.1128/IAI.66.4.1453-1459.1998.
2
Epithelial cell polarity affects susceptibility to Pseudomonas aeruginosa invasion and cytotoxicity.上皮细胞极性影响对铜绿假单胞菌侵袭和细胞毒性的易感性。
Infect Immun. 1997 Jul;65(7):2861-7. doi: 10.1128/iai.65.7.2861-2867.1997.
3
Hepatocyte growth factor alters the polarity of Madin-Darby canine kidney cell monolayers.肝细胞生长因子改变了Madin-Darby犬肾细胞单层的极性。
J Biol Chem. 1997 Feb 7;272(6):3471-7. doi: 10.1074/jbc.272.6.3471.
4
Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S.铜绿假单胞菌介导的细胞毒性和侵袭与编码外毒素S的基因座处的不同基因型相关。
Infect Immun. 1997 Feb;65(2):579-86. doi: 10.1128/iai.65.2.579-586.1997.
5
Exoenzyme S of Pseudomonas aeruginosa is secreted by a type III pathway.铜绿假单胞菌的外毒素S通过III型分泌途径分泌。
Mol Microbiol. 1996 Dec;22(5):991-1003. doi: 10.1046/j.1365-2958.1996.01554.x.
6
Significant elevation of serum human hepatocyte growth factor levels in patients with acute pancreatitis.急性胰腺炎患者血清人肝细胞生长因子水平显著升高。
Pancreas. 1996 Jan;12(1):76-83. doi: 10.1097/00006676-199601000-00010.
7
Relationship between cytotoxicity and corneal epithelial cell invasion by clinical isolates of Pseudomonas aeruginosa.铜绿假单胞菌临床分离株的细胞毒性与角膜上皮细胞侵袭之间的关系
Infect Immun. 1996 Jun;64(6):2288-94. doi: 10.1128/iai.64.6.2288-2294.1996.
8
Hepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland, tears, and cornea.泪腺、泪液及角膜中的肝细胞生长因子和肝细胞生长因子受体。
Invest Ophthalmol Vis Sci. 1996 Apr;37(5):727-39.
9
E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cells.E-钙黏蛋白是内化素的受体，内化素是单核细胞增生李斯特菌进入上皮细胞所必需的一种表面蛋白。
Cell. 1996 Mar 22;84(6):923-32. doi: 10.1016/s0092-8674(00)81070-3.
10
Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections.突变型囊性纤维化跨膜传导调节因子在囊性纤维化患者对肺部感染高度易感性中的作用。
Science. 1996 Jan 5;271(5245):64-7. doi: 10.1126/science.271.5245.64.
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