在DATATOP研究中服用高剂量维生素E的受试者脑脊液中的α-生育酚。帕金森研究小组。
Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group.
作者信息
Vatassery G T, Fahn S, Kuskowski M A
机构信息
GRECC, VA Medical Center, Department of Psychiatry, University of Minnesota, Minneapolis 55417, USA.
出版信息
Neurology. 1998 Jun;50(6):1900-2. doi: 10.1212/wnl.50.6.1900.
Alpha-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76+/-10 (SE)%. The net increases in CSF alpha-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.
对早期未经治疗且每日口服2000国际单位维生素E的帕金森病患者的脑脊液进行了α-生育酚浓度测定。治疗后，浓度显著升高（p<0.001），升高了76±10（标准误）%。治疗后脑脊液α-生育酚浓度的净升高与维生素E摄入天数呈显著正相关（p<0.001）。因此，高剂量维生素E治疗可提高脑脊液维生素E水平，并可能提高脑内维生素E水平。
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