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美国年轻人中艾滋病毒感染率的趋势。

Trends in HIV incidence among young adults in the United States.

作者信息

Rosenberg P S, Biggar R J

机构信息

Biostatistics Branch, National Cancer Institute, Bethesda, MD 20892, USA.

出版信息

JAMA. 1998 Jun 17;279(23):1894-9. doi: 10.1001/jama.279.23.1894.

Abstract

CONTEXT

Behaviors that result in potential exposure to human immunodeficiency virus (HIV) usually begin in adolescence or young adulthood, but trends in HIV incidence in young people remain unclear.

OBJECTIVE

To estimate trends in HIV incidence in teenagers and young adults.

DESIGN AND SETTING

Back-calculation of past HIV incidence in persons born between 1960 and 1974 using US national acquired immunodeficiency syndrome (AIDS) incidence data and estimates of the distribution of times between HIV infection and AIDS.

MAIN OUTCOME MEASURES

Incidence and prevalence of HIV in 1988 and 1993 in persons aged 20 and 25 years, respectively, in each of those years.

RESULTS

As of January 1993, about 22000 men and 11000 women aged 18 to 22 years were living with HIV infection in the United States. Homosexual contact was the leading route of infection among young men. Heterosexual contact was the leading route of infection among young women. The HIV incidence attributed to homosexual contact or injection drug use decreased among persons aged 20 and 25 years between 1988 and 1993, but HIV incidence attributed to heterosexual contact was stable or increasing. Notably, in men aged 20 and 25 years, HIV prevalence declined by about 50% in white men but was relatively stable in black and Hispanic men. In contrast, HIV prevalence in women aged 20 and 25 years rose by 36% and 45%, respectively, because of increasing heterosexual transmission. Overall, HIV prevalence in persons aged 20 and 25 years declined by only 14% between 1988 and 1993.

CONCLUSIONS

In young persons, HIV incidence in homosexual men and injection drug users was slowing by 1993; this favorable trend was offset by increasing heterosexual transmission, especially in minorities.

摘要

背景

导致潜在感染人类免疫缺陷病毒(HIV)的行为通常始于青春期或青年期,但年轻人中HIV发病率的趋势仍不明确。

目的

评估青少年和青年中HIV发病率的趋势。

设计与研究地点

利用美国全国获得性免疫缺陷综合征(AIDS)发病率数据以及HIV感染与AIDS发病间隔时间分布的估计值,对1960年至1974年出生人群过去的HIV发病率进行反向推算。

主要观察指标

1988年和1993年分别为20岁和25岁人群中HIV的发病率和患病率。

结果

截至1993年1月,美国约有22000名18至22岁的男性和11000名女性感染了HIV。同性恋接触是年轻男性的主要感染途径。异性恋接触是年轻女性的主要感染途径。1988年至1993年间,20岁和25岁人群中因同性恋接触或注射吸毒导致的HIV发病率有所下降,但因异性恋接触导致的HIV发病率稳定或上升。值得注意的是,在20岁和25岁的男性中,白人男性的HIV患病率下降了约50%,而黑人男性和西班牙裔男性的患病率相对稳定。相比之下,20岁和25岁女性的HIV患病率分别上升了36%和45%,原因是异性传播增加。总体而言,1988年至1993年间,20岁和25岁人群的HIV患病率仅下降了14%。

结论

到1993年,年轻男性同性恋者和注射吸毒者中的HIV发病率正在放缓;这一有利趋势被异性传播增加所抵消,尤其是在少数族裔中。

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