Kita S, Matsumura Y, Morimoto S, Akimoto K, Furuya M, Oka N, Tanaka T
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan.
Biol Pharm Bull. 1995 Sep;18(9):1283-5. doi: 10.1248/bpb.18.1283.
We investigated the antihypertensive effect of sesamin, a lignan from sesame oil, using two-kidney, one-clip (2K,1C) renal hypertensive rats. After clipping the left renal artery, animals were assigned to either a normal diet group (control group) or a sesamin-containing (1% (w/w)) diet group (sesamin group). The sham-operated rats (sham group) were fed a normal diet and tap water. The systolic blood pressure of the control group increased progressively in comparison with the sham group. This 2K,1C-induced hypertension was markedly reduced by feeding the sesamin-containing diet. The systolic blood pressure after 4 weeks was 123.60 +/- 4.01 mmHg in the sham group, 187.43 +/- 5.69 mmHg in the control group and 145.57 +/- 6.78 mmHg in the sesamin group, respectively. There were significant increases in left ventricle plus septum weight-body weight ratio in the control group compared with the sham group. This rise was also significantly reduced in the sesamin group. When the thoracic aorta was histochemically evaluated, the wall thickness and wall-to-lumen ratio in the control group were significantly increased, compared with the sham group, indicating that vascular hypertrophy had occurred in the control group. The sesamin diet tended to ameliorate this vascular hypertrophy, although its effect was not statistically significant. These findings suggest that sesamin is useful as prophylactic treatment to combat the development of renal hypertension and cardiac hypertrophy.
我们使用两肾一夹（2K，1C）肾性高血压大鼠研究了芝麻油木脂素芝麻素的降压作用。夹闭左肾动脉后，将动物分为正常饮食组（对照组）或含芝麻素（1%（w/w））饮食组（芝麻素组）。假手术大鼠（假手术组）喂食正常饮食和自来水。与假手术组相比，对照组的收缩压逐渐升高。喂食含芝麻素的饮食可显著降低这种由2K，1C诱导的高血压。4周后的收缩压在假手术组为123.60±4.01 mmHg，对照组为187.43±5.69 mmHg，芝麻素组为145.57±6.78 mmHg。与假手术组相比，对照组左心室加室间隔重量与体重之比显著增加。芝麻素组的这种升高也显著降低。当对胸主动脉进行组织化学评估时，与假手术组相比，对照组的壁厚和壁腔比显著增加，表明对照组发生了血管肥大。芝麻素饮食倾向于改善这种血管肥大，尽管其效果无统计学意义。这些发现表明，芝麻素可作为预防肾性高血压和心脏肥大发展的有效治疗方法。
