一种抗肿瘤多糖——香菇多糖生物活性表达的多基因控制

Polygenic control of the expression of biological activities of an antitumor polysaccharide, lentinan.

作者信息

Maeda Y Y, Takahama S, Kohara Y, Yonekawa H

机构信息

Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Japan.

出版信息

Int J Immunopharmacol. 1997 Sep-Oct;19(9-10):469-72. doi: 10.1016/s0192-0561(97)00082-9.

DOI:10.1016/s0192-0561(97)00082-9

PMID:9637340

Abstract

Genetic studies were carried out on two in vivo responses of lentinan, delayed type-acute phase responses (DT-APR) and vascular dilation and hemorrhage (VDH). Linkage analyses showed that DT-APR was controlled by two recessive genes, ltnr1 and ltnr2, which were mapped on chromosome 3 and 11, respectively. VDH was also found to be controlled by polygenes. One dominant major gene, Ltnr3, and three dominant minor genes, Ltnr4, Ltnr5, and Ltnr6, were mapped on chromosomes 6, 9, 15 and 16, respectively.

摘要

对香菇多糖的两种体内反应，即迟发型急性期反应（DT-APR）和血管扩张与出血（VDH）进行了遗传学研究。连锁分析表明，DT-APR由两个隐性基因ltnr1和ltnr2控制，它们分别位于3号和11号染色体上。还发现VDH受多基因控制。一个显性主基因Ltnr3和三个显性微效基因Ltnr4、Ltnr5和Ltnr6分别位于6号、9号、15号和16号染色体上。