Suzuki M, Takatsuki F, Maeda Y Y, Hamuro J, Chihara G
Basic Research Laboratories, Ajinomoto Co. Inc., Kawasaki, Japan.
Int J Immunopharmacol. 1994 May-Jun;16(5-6):463-8. doi: 10.1016/0192-0561(94)90037-x.
Lentinan manifests marked antitumor and antimetastatic activity in numerous tumor/host systems, and prevents chemical and viral carcinogenesis. Modulation of immune or vascular functions by lentinan is involved in its antitumor effects. The impact of lentinan on the functions of macrophages is distinct from that of LPS. One of the effects of lentinan on the vascular system is the vascular dilatation and hemorrhage (VDH) reaction, and the effect can be monitored as augmented skin reactions to vasoactive mediators. Lentinan induces the VDH-like reaction at the tumor site, resulting in the induction of hemorrhagic necrosis and complete regression of the tumor. In contrast to LPS-induced tumor necrosis (Shwartzman's-like reaction), lentinan-induced tumor necrosis is T-cell dependent.
香菇多糖在众多肿瘤/宿主系统中表现出显著的抗肿瘤和抗转移活性，并可预防化学致癌和病毒致癌。香菇多糖对免疫或血管功能的调节作用涉及其抗肿瘤效果。香菇多糖对巨噬细胞功能的影响与脂多糖不同。香菇多糖对血管系统的作用之一是血管扩张和出血（VDH）反应，这种作用可通过对血管活性介质的皮肤反应增强来监测。香菇多糖在肿瘤部位诱导VDH样反应，导致出血性坏死的诱导和肿瘤的完全消退。与脂多糖诱导的肿瘤坏死（类施瓦茨曼反应）不同，香菇多糖诱导的肿瘤坏死依赖于T细胞。
