Maeda Y Y, Watanabe S T, Chihara G, Rokutanda M
Int J Immunopharmacol. 1984;6(5):493-501. doi: 10.1016/0192-0561(84)90088-2.
Antitumour polysaccharide lentinan, capable of potentiating T-cell dependent reactions and some other antitumour polysaccharides such as pachymaran, carboxymethyl-pachymaran and zymosan were found to induce vascular dilatation and hemorrhage(VDH) in CD-1 normal mice starting the following day after a single injection. Polysaccharides which do not have the tumour-regressing activity, several immunopotentiators such as BCG, lipopolysaccharide, dextran sulfate and concanavalin A, and chemical mediators of inflammation such as histamine, serotonin and prostaglandin E1 did not induce VDH in mice. This response seems to be mediated by T-cells and macrophages, because VDH was not observed in CD-1 nu/nu mice treated with lentinan, and carrageenan, an antimacrophage drug, inhibited the appearance of VDH by lentinan. Furthermore, carrageenan inhibited the production of the VDH-inducing serum which was caused by lentinan, capable of passively transferring VDH to another mouse.
抗肿瘤多糖香菇多糖能够增强T细胞依赖性反应，一些其他抗肿瘤多糖，如茯苓聚糖、羧甲基茯苓聚糖和酵母聚糖，在单次注射后的第二天开始，会在CD-1正常小鼠中诱导血管扩张和出血（VDH）。没有肿瘤消退活性的多糖、几种免疫增强剂，如卡介苗、脂多糖、硫酸葡聚糖和伴刀豆球蛋白A，以及炎症化学介质，如组胺、血清素和前列腺素E1，均不会在小鼠中诱导VDH。这种反应似乎是由T细胞和巨噬细胞介导的，因为在用香菇多糖处理的CD-1裸鼠中未观察到VDH，并且角叉菜胶（一种抗巨噬细胞药物）抑制了香菇多糖诱导的VDH的出现。此外，角叉菜胶抑制了由香菇多糖引起的、能够将VDH被动转移到另一只小鼠的VDH诱导血清的产生。
