Massé P G, Van den Berg H, Livingstone M M, Duguay C, Beaulieu G
Université De Moncton, School of Nutrition/Family Studies, New Brunswick, Canada.
Int J Vitam Nutr Res. 1998;68(3):203-7.
The present study was aimed to assess the psychological status of young healthy women after the administration of a triphasic contraceptive steroid preparation for six complete menstrual cycles. Subjects had never used oral contraceptives (OC) and had neither a familial history of depression nor psychological disturbances. OC-induced psychological disturbances were interpreted for years as evidence of pyridoxine (vitamin B6) deficiency. Other nutritional deficiencies, namely in cobalamin, folate and iron, can disturb the functioning of the central nervous system. In addition, a deficiency of any of these nutrients can lead to several anemia-induced symptoms that are highly susceptible to influence the psychological status. For ample evidence, nutritional status was then evaluated in parallel to psychological testing. Blood iron and vitamin levels of interest were found to be adequate and could not have biased the response to a psychological test (MMPI). This study showed that a 6-month Triphasil treatment did not modify significantly the psychological status of subjects. To our knowledge, this is the first psychological study on young never OC-users taking an identical triphasic contraceptive steroid preparation to investigate early psychological side-effects due to OC, at a similar time of the menstrual cycle, when nutritional status was also evaluated.
本研究旨在评估年轻健康女性在服用三相避孕甾体制剂六个完整月经周期后的心理状态。研究对象从未使用过口服避孕药（OC），且既无抑郁症家族史也无心理障碍。多年来，OC引起的心理障碍一直被解释为吡哆醇（维生素B6）缺乏的证据。其他营养缺乏，即钴胺素、叶酸和铁的缺乏，会干扰中枢神经系统的功能。此外，这些营养素中的任何一种缺乏都可能导致几种贫血引起的症状，这些症状极易影响心理状态。为了提供充分的证据，在进行心理测试的同时对营养状况进行了评估。发现所关注的血铁和维生素水平充足，不会对心理测试（明尼苏达多相人格调查表）的反应产生偏差。本研究表明，6个月的三相避孕片治疗并未显著改变研究对象的心理状态。据我们所知，这是第一项针对从未使用过OC的年轻女性进行的心理学研究，她们服用相同的三相避孕甾体制剂，在月经周期的相似时间调查OC引起的早期心理副作用，同时也评估了营养状况。
