牛肠道病毒日本分离株RNA聚合酶编码基因及3'非编码区的核苷酸序列：欧洲株与日本株之间的快速同义替换
Nucleotide sequence of the gene encoding the RNA polymerase and the 3' non-coding region of a bovine enterovirus Japanese isolate: rapid synonymous substitutions between European and Japanese strains.
作者信息
Hamada N, Masunaga K, Ohtsu Y, Kato H, Tsuji K, Maeda H, Shingu M, Toyoda T
机构信息
Department of Virology, Kurume University School of Medicine, Fukuoka, Japan.
出版信息
Arch Virol. 1998;143(4):815-21. doi: 10.1007/s007050050333.
The nucleotide sequences of the genome RNA encoding the RNA polymerase and the 3' non-coding region (NCR) of bovine enterovirus (BEV) serotype I Japanese isolate, MZ468, were determined. The genetic distance between the two BEV serotype I strains, MZ468 and VG-5-27, was calculated by pairwise comparison of nucleotide sequences. The synonymous substitution rate was high (1.40 x 10(-2)/site/year), and of the same order as those of influenza virus HA, HIV-1 gag and env, and enterovirus 70 VP1 genes.
测定了编码牛肠道病毒（BEV）I型日本分离株MZ468的RNA聚合酶的基因组RNA的核苷酸序列以及3'非编码区（NCR）。通过对核苷酸序列进行成对比较，计算了两种BEV I型毒株MZ468和VG-5-27之间的遗传距离。同义替换率很高（1.40×10⁻²/位点/年），与流感病毒HA、HIV-1 gag和env以及肠道病毒70 VP1基因的同义替换率处于同一水平。
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