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铁在丙型肝炎疾病自然史和临床病程中的作用。

Role of iron in the natural history and clinical course of hepatitis C disease.

作者信息

Shedlofsky S I

机构信息

University of Kentucky College of Medicine, Lexington, USA.

出版信息

Hepatogastroenterology. 1998 Mar-Apr;45(20):349-55.

PMID:9638405
Abstract

The following review evaluates the current data implicating a role for hepatic iron in enhancing the liver injury in patients with chronic hepatitis C infection. Iron removal lowers transaminases, but doesn't appear to improve responsiveness to interferon-alpha therapy. An important effect of iron removal might be to delay progression of liver injury to fibrosis and cirrhosis. Until such a hypothesis is disproven, phlebotomy therapy for even mildly iron-loaded HCV patients is recommended.

摘要

以下综述评估了当前有关肝铁在加重慢性丙型肝炎感染患者肝损伤中所起作用的数据。铁去除可降低转氨酶，但似乎并未改善对α干扰素治疗的反应性。铁去除的一个重要作用可能是延缓肝损伤向纤维化和肝硬化的进展。在这一假说被证伪之前，建议对即使轻度铁过载的丙型肝炎患者进行放血治疗。

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