Simms R W
Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA.
Am J Med Sci. 1998 Jun;315(6):346-50. doi: 10.1097/00000441-199806000-00002.
Originally described as "fibrositis," fibromyalgia has long been considered a muscle disorder, and many studies have investigated the possible pathologic basis of the disorder by examining muscle tissue, using various methodologic approaches. Although initial studies suggested a possible pathologic basis in muscle, most had serious methodologic limitations. More recent studies, however, have avoided methodologic pitfalls and indicate that the muscles of patients with fibromyalgia are normal. When data from studies of tenderness are also taken into account, the weight of evidence suggests that fibromyalgia is a chronic pain syndrome which has a central rather than peripheral or muscular basis.
纤维肌痛最初被描述为“纤维织炎”,长期以来一直被认为是一种肌肉疾病,许多研究通过各种方法研究肌肉组织,以探究该疾病可能的病理基础。尽管最初的研究表明肌肉可能存在病理基础,但大多数研究都存在严重的方法学局限性。然而,最近的研究避免了方法学上的缺陷,表明纤维肌痛患者的肌肉是正常的。当也考虑到压痛研究的数据时,证据表明纤维肌痛是一种慢性疼痛综合征,其基础是中枢性的而非外周性或肌肉性的。