Swinhoe C F, Peacock J E, Glen J B, Reilly C S
Anaesthetic Department, Barnsley District General Hospital, South Yorkshire, UK.
Anaesthesia. 1998 Apr;53 Suppl 1:61-7. doi: 10.1111/j.1365-2044.1998.53s104.x.
The predictive performance of a 'Diprifusor' target controlled infusion system for propofol was examined in 46 patients undergoing major surgery, divided into three age groups (18-40, 41-55 and 56-80 years). Measured arterial propofol concentrations were compared with values calculated (predicted) by the target controlled infusion system. Performance indices (median performance error and median absolute performance error) were similar in the three age groups, with study medians of 16.2% and 24.1%, respectively. Mean values for 'divergence' and 'wobble' were -7.6%.h-1 and 21.9%, respectively. Measured concentrations tended to be higher than calculated concentrations, particularly following induction or an increase in target concentration. The mean (SD) propofol target concentration of 3.5 (0.7) micrograms.ml-1 during maintenance was lower in older patients, compared with higher target concentrations of 4.2 (0.6) and 4.3 (0.7) micrograms.ml-1 in the two younger age groups, respectively. The control of depth of anaesthesia was good in all patients and the predictive performance of the 'Diprifusor' target controlled infusion system was considered acceptable for clinical purposes.
在46例接受大手术的患者中，对“Diprifusor”丙泊酚靶控输注系统的预测性能进行了研究，这些患者被分为三个年龄组（18 - 40岁、41 - 55岁和56 - 80岁）。将测量的动脉丙泊酚浓度与靶控输注系统计算（预测）的值进行比较。三个年龄组的性能指标（中位性能误差和中位绝对性能误差）相似，研究中位数分别为16.2%和24.1%。“偏差”和“摆动”的平均值分别为-7.6%·h⁻¹和21.9%。测量浓度往往高于计算浓度，尤其是在诱导后或靶浓度增加后。与两个较年轻年龄组分别为4.2（0.6）和4.3（0.7）μg·ml⁻¹的较高靶浓度相比，老年患者维持期间丙泊酚的平均（标准差）靶浓度为3.5（0.7）μg·ml⁻¹较低。所有患者的麻醉深度控制良好，“Diprifusor”靶控输注系统的预测性能在临床应用中被认为是可以接受的。
