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SMC蛋白复合体与高阶染色体动力学

SMC protein complexes and higher-order chromosome dynamics.

作者信息

Hirano T

机构信息

Cold Spring Harbor Laboratory, New York, USA.

出版信息

Curr Opin Cell Biol. 1998 Jun;10(3):317-22. doi: 10.1016/s0955-0674(98)80006-9.

DOI:10.1016/s0955-0674(98)80006-9
PMID:9640531
Abstract

The structural maintenance of chromosome (SMC) family of proteins represents an expanding group of chromosomal ATPases that are highly conserved among Bacteria, Archaea and Eukarya. During the past year, significant progress has been made towards understanding the cellular functions and molecular activities of this new class of proteins. Emerging evidence suggests that eukaryotic SMC proteins form large protein complexes with non-SMC subunits and act as key components for a wide variety of higher-order chromosome dynamics.

摘要

染色体结构维持（SMC）蛋白家族是一类不断扩展的染色体ATP酶，在细菌、古细菌和真核生物中高度保守。在过去的一年里，在理解这类新蛋白的细胞功能和分子活性方面取得了重大进展。新出现的证据表明，真核生物的SMC蛋白与非SMC亚基形成大型蛋白复合物，并作为多种高阶染色体动态变化的关键成分发挥作用。

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1
SMC protein complexes and higher-order chromosome dynamics.SMC蛋白复合体与高阶染色体动力学
Curr Opin Cell Biol. 1998 Jun;10(3):317-22. doi: 10.1016/s0955-0674(98)80006-9.
2
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3
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Condensin-Based Chromosome Organization from Bacteria to Vertebrates.从细菌到脊椎动物的基于凝聚蛋白的染色体组织
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Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions.染色体结构维持（SMC）蛋白：多种生物学功能的保守分子特性
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A novel SMC-like protein, SbcE (YhaN), is involved in DNA double-strand break repair and competence in Bacillus subtilis.新型 SMC 样蛋白 SbcE（YhaN）参与枯草芽孢杆菌 DNA 双链断裂修复和感受态形成。
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Smc5p promotes faithful chromosome transmission and DNA repair in Saccharomyces cerevisiae.
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DNA reshaping by MukB. Right-handed knotting, left-handed supercoiling.由MukB介导的DNA重塑。右手打结，左手超螺旋。
J Biol Chem. 2006 Feb 24;281(8):4606-15. doi: 10.1074/jbc.M504754200. Epub 2005 Dec 20.
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Micromechanical studies of mitotic chromosomes.有丝分裂染色体的微机械研究。
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