Johnson F B, Marciniak R A, Guarente L
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
Curr Opin Cell Biol. 1998 Jun;10(3):332-8. doi: 10.1016/s0955-0674(98)80008-2.
Reactivation of telomerase in cultured human cells extends their replicative life span beyond the Hayflick limit. How telomere shortening triggers cell senescence and whether it contributes to aging in vivo are under investigation. Studies in yeast have revealed another site critical to cellular aging: the nucleolus. The accumulation of ribosomal DNA circles is a cause of aging in this organism. The possible relevance of this mechanism to human aging is also being considered.
在培养的人类细胞中，端粒酶的重新激活将其复制寿命延长至超过海弗利克极限。端粒缩短如何触发细胞衰老以及它是否在体内导致衰老仍在研究中。对酵母的研究揭示了另一个对细胞衰老至关重要的部位：核仁。核糖体DNA环的积累是这种生物体衰老的一个原因。这种机制与人类衰老的可能相关性也正在被考虑。
