a Department of Biochemistry and Cell Biology , University of Rzeszow , Rzeszow , Poland.
b Department of Genetics , University of Rzeszow , Rzeszow , Poland.
Cell Cycle. 2018;17(10):1173-1187. doi: 10.1080/15384101.2018.1464846. Epub 2018 Jul 15.
Although a lot of effort has been put into the search for factors responsible for aging in yeast mother cells, our knowledge of cellular changes in daughter cells originating from old mothers is still very limited. It has been shown that an old mother is not able to compensate for all negative changes within its cell and therefore transfers them to the bud. In this paper, we show for the first time that daughter cells of an old mother have a reset lifespan expressed in units of time despite drastic reduction of their budding lifespan, which suggests that a single yeast cell has a fixed programmed longevity regardless of the time point at which it was originated. Moreover, in our study we found that longevity parameters are not correlated with the rDNA level, DNA damage, chromosome structure or aging parameters (budding lifespan and total lifespan).
尽管人们在寻找导致酵母母细胞衰老的因素方面付出了大量努力，但我们对源自年老母细胞的子细胞的细胞变化的了解仍然非常有限。已经表明，年老的母细胞无法弥补其细胞内的所有负面变化，并因此将其传递给芽。在本文中，我们首次表明，尽管母细胞的出芽寿命急剧缩短，但来自年老母细胞的子细胞的寿命在时间单位上重置，这表明单个酵母细胞具有固定的程序性寿命，而与它起源的时间点无关。此外，在我们的研究中，我们发现寿命参数与 rDNA 水平、DNA 损伤、染色体结构或衰老参数（出芽寿命和总寿命）无关。
