Jacques M, Paradis S E
Groupe de Recherche sur les Maladies Infectieuses du Pord, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, Québec, Canada.
FEMS Microbiol Rev. 1998 Apr;22(1):45-59. doi: 10.1016/s0168-6445(98)00007-2.
The ability of bacteria to adhere to mucosal epithelium is dependent on the expression of adhesive molecules or structures, called adhesins, that allow attachment of the organisms to complementary molecules on mucosal surfaces, the receptors. Important human and animal pathogens are found among the Pasteurellaceae family which includes Haemophilus, Actinobacillus, and Pasteurella organisms. The purpose of this paper is to review the adhesin-receptor systems found in Pasteurellaceae, with an emphasis on recent developments in this specific area. Most of these organisms can employ multiple molecular mechanisms of adherence (or multiple adhesins) to initiate infection. Indeed, a wide variety of adhesins are expressed by members of the Pasteurellaceae, and different proteins (e.g. fimbriae, fibrils, outer membrane proteins) as well as polysaccharides (lipooligosaccharides, lipopolysaccharides, capsular polysaccharides) were clearly shown to play an important role in adherence. In many instances, these adhesins have proved to represent good vaccine candidates. Surprisingly, the receptors on host mucosal surfaces have yet been identified in very few cases.
细菌黏附于黏膜上皮的能力取决于黏附分子或结构（称为黏附素）的表达，这些黏附素使微生物能够附着于黏膜表面的互补分子即受体上。巴斯德氏菌科中发现了重要的人类和动物病原体，该科包括嗜血杆菌属、放线杆菌属和巴斯德氏菌属微生物。本文的目的是综述巴斯德氏菌科中发现的黏附素 - 受体系统，重点关注这一特定领域的最新进展。这些微生物大多可采用多种黏附分子机制（或多种黏附素）来引发感染。事实上，巴斯德氏菌科成员表达多种黏附素，不同的蛋白质（如菌毛、纤丝、外膜蛋白）以及多糖（脂寡糖、脂多糖、荚膜多糖）均在黏附中发挥重要作用。在许多情况下，这些黏附素已被证明是良好的疫苗候选物。令人惊讶的是，宿主黏膜表面的受体在极少数情况下才被鉴定出来。
