Carvalho M F, de Franco M F, Soares V A
Departamento de Clínica Médica, Faculdade de Medicina de Botucatu/UNESP, SP, Brasil.
Rev Inst Med Trop Sao Paulo. 1997 Jul-Aug;39(4):223-6. doi: 10.1590/s0036-46651997000400008.
Trypanosoma cruzi, the causative agent of Chagas' disease assumes two distinct forms in vertebrate hosts: circulating trypomastigote and tissular amastigote. This latter form infects predominantly the myocardium, smooth and skeletal muscle, and central nervous system. The present work describes for the first time the detection of amastigote forms of T. cruzi in the renal parenchyma of a kidney graft recipient one month after transplantation. The patient was serologically negative for Chagas' disease and received no blood transfusion prior to transplant. The cadaver donor was from an endemic area for Chagas' disease. The recipient developed the acute form of the disease with detection of amastigote forms of T. cruzi in the renal allograft biopsy and circulating trypomastigote forms. The present report demonstrates that T. cruzi can infect the renal parenchyma. This mode of transmission warrants in endemic areas of Chagas' disease.
克氏锥虫是恰加斯病的病原体，在脊椎动物宿主中呈现两种不同形态：循环型锥鞭毛体和组织内无鞭毛体。后一种形态主要感染心肌、平滑肌和骨骼肌以及中枢神经系统。本研究首次描述了在肾移植受者移植后一个月的肾实质中检测到克氏锥虫的无鞭毛体形态。该患者恰加斯病血清学检测为阴性，移植前未接受输血。尸体供体来自恰加斯病流行地区。受者发展为该病的急性形式，在肾移植活检中检测到克氏锥虫的无鞭毛体形态以及循环型锥鞭毛体形态。本报告表明克氏锥虫可感染肾实质。在恰加斯病流行地区，这种传播方式值得关注。
