Fraschini F, Demartini G, Esposti D, Scaglione F
Department of Pharmacology, University of Milan, Italy.
Biol Signals Recept. 1998 Jan-Feb;7(1):61-72. doi: 10.1159/000014529.
The most studied endocrine product of the pineal gland, melatonin, has been reported to be involved in the feedback between neuroendocrine and immune functions and to exert oncostatic action, at least in certain experimental conditions. Melatonin seems to be an integral part of the immune system, by exerting direct and/or indirect stimulatory effects on both cellular and humoral immunity. Likewise, an antitumor activity of melatonin has been shown in several experimental models in vivo and in vitro. The means by which melatonin exerts its effects on immunity and neoplastic growth have not been elucidated. The different putative mechanisms of action of melatonin investigated so far are here briefly discussed.
松果体研究最多的内分泌产物褪黑素，据报道参与神经内分泌和免疫功能之间的反馈，并至少在某些实验条件下发挥抑癌作用。褪黑素似乎是免疫系统不可或缺的一部分，对细胞免疫和体液免疫均有直接和/或间接的刺激作用。同样，褪黑素的抗肿瘤活性已在多个体内和体外实验模型中得到证实。褪黑素对免疫和肿瘤生长发挥作用的机制尚未阐明。本文简要讨论了迄今为止所研究的褪黑素不同的假定作用机制。
