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金黄色葡萄球菌胞外蛋白A的形成。

Formation of extracellular protein A by Staphylococcus aureus.

作者信息

Movitz J

出版信息

Eur J Biochem. 1976 Sep;68(1):291-9. doi: 10.1111/j.1432-1033.1976.tb10788.x.

DOI:10.1111/j.1432-1033.1976.tb10788.x
PMID:964266
Abstract

Staphylococcus aureus contains cell wall protein A as well as extracellular protein A. The two types of protein A have very similar amino acid compositions, electrophoretic mobilities and sizes. The release of extracellular protein A from exponentially growing bacteria is dependent on protein synthesis de novo and protein A is released directly after being synthesized on the ribosomes. Bacteria in the stationary phase, however, release protein A as a result of cell lysis. Protoplasts have been isolated which produce protein A as extensively as the intact bacteria but because of the absence of of the formation of extracellular protein A is observed from cells also producing cell wall protein A.

摘要

金黄色葡萄球菌含有细胞壁蛋白A以及细胞外蛋白A。这两种类型的蛋白A具有非常相似的氨基酸组成、电泳迁移率和大小。指数生长期细菌释放细胞外蛋白A依赖于从头合成蛋白质,并且蛋白A在核糖体上合成后直接释放。然而,稳定期的细菌由于细胞裂解而释放蛋白A。已经分离出原生质体,其产生蛋白A的程度与完整细菌一样广泛,但由于缺乏细胞壁,从也产生细胞壁蛋白A的细胞中观察到细胞外蛋白A的形成。

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