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与HIV感染相关的美洲皮肤利什曼病:4例报告。

American cutaneous leishmaniasis associated with HIV infection: report of four cases.

作者信息

Mattos M, Caiza A, Fernandes O, Gonçalves A J, Pirmez C, Souza C S, Oliveira-Neto M P

机构信息

Hospital Evandro Chagas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.

出版信息

J Eur Acad Dermatol Venereol. 1998 May;10(3):218-25.

PMID:9643324
Abstract

OBJECTIVE

A report of four cases of American cutaneous leishmaniasis associated with HIV infection is presented.

BACKGROUND

The association of mucocutaneous leishmaniasis and HIV infection is rare. Only 15 cases have been reported in the literature thus far.

SUBJECTS

Four new cases are described and the differences between the clinical presentation in immunocompromised and immunocompetent patients are emphasized.

CONCLUSIONS

Multiple cutaneous lesions plus mucosal involvement characterize the clinical presentation of American cutaneous leishmaniasis in association with HIV infection in the majority of the cases. A serological investigation for HIV infection is recommended for patients presenting with this type of clinical picture, especially if the patient is a young male.

摘要

目的

报告4例与HIV感染相关的美洲皮肤利什曼病病例。

背景

黏膜皮肤利什曼病与HIV感染的关联罕见。迄今为止,文献中仅报道了15例。

研究对象

描述4例新病例,并强调免疫功能低下患者与免疫功能正常患者临床表现的差异。

结论

在大多数病例中,多发性皮肤病变加黏膜受累是与HIV感染相关的美洲皮肤利什曼病的临床表现特征。对于出现此类临床表现的患者,尤其是年轻男性患者,建议进行HIV感染的血清学调查。

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American mucocutaneous leishmaniasis.美洲皮肤黏膜利什曼病
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Leishmaniasis-HIV coinfection: current challenges.利什曼病与艾滋病病毒合并感染:当前挑战
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PKDL and other dermal lesions in HIV co-infected patients with Leishmaniasis: review of clinical presentation in relation to immune responses.
合并感染HIV的利什曼病患者的皮肤利什曼病后皮肤黏膜病变及其他皮肤病变:与免疫反应相关的临床表现综述
PLoS Negl Trop Dis. 2014 Nov 20;8(11):e3258. doi: 10.1371/journal.pntd.0003258. eCollection 2014.
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The impact of human immunodeficiency virus (HIV) co-infection on the economic burden of cutaneous leishmaniasis (CL) in Brazil and potential value of new CL drug treatments.人类免疫缺陷病毒(HIV)合并感染对巴西皮肤利什曼病(CL)经济负担的影响以及新型CL药物治疗的潜在价值。
Am J Trop Med Hyg. 2014 Sep;91(3):520-527. doi: 10.4269/ajtmh.13-0309. Epub 2014 Jul 7.
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Th1/Th2 cytokine profile in patients coinfected with HIV and Leishmania in Brazil.巴西同时感染艾滋病毒和利什曼原虫患者的Th1/Th2细胞因子谱
Clin Vaccine Immunol. 2011 Oct;18(10):1765-9. doi: 10.1128/CVI.00076-11. Epub 2011 Aug 10.
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High levels of T lymphocyte activation in Leishmania-HIV-1 co-infected individuals despite low HIV viral load.尽管 HIV 病毒载量低,但利什曼原虫-HIV-1 合并感染个体中的 T 淋巴细胞激活水平较高。
BMC Infect Dis. 2010 Dec 20;10:358. doi: 10.1186/1471-2334-10-358.
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The relationship between leishmaniasis and AIDS: the second 10 years.利什曼病与艾滋病的关系:第二个十年
Clin Microbiol Rev. 2008 Apr;21(2):334-59, table of contents. doi: 10.1128/CMR.00061-07.