Daniel Y, Kupferminc M J, Baram A, Jaffa A J, Fait G, Wolman I, Lessing J B
Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Am J Reprod Immunol. 1998 Jun;39(6):376-80. doi: 10.1111/j.1600-0897.1998.tb00372.x.
Abnormal immune activation has been suggested as a contributor to the development of preeclampsia. We hypothesized that intact interleukin (IL)-12 directly, or through its main mediator, interferon (IFN)-gamma, contributes to the altered immune response observed in preeclampsia.
Plasma samples were collected from 20 patients with preeclampsia and 20 normotensive patients with uncomplicated pregnancies who were matched with the preeclamptic patients by age, gestational age, and parity. Samples were collected before the onset of labor, induction, or medical intervention. The samples were assayed for IL-12 and IFN-gamma by specific enzyme-linked immunoassays.
IL-12 was detected in 35% of the preeclamptic patients and in 5% of the patients with normal pregnancies (P < 0.01). The detection rate and mean concentration of IFN-gamma were comparable in both groups.
Intact plasma IL-12 is detected more frequently in preeclamptic patients, suggesting the involvement of this cytokine in the enhanced immune response observed in preeclampsia.
异常免疫激活被认为是子痫前期发病的一个因素。我们推测完整的白细胞介素（IL）-12直接或通过其主要介质干扰素（IFN）-γ，促成了子痫前期中观察到的免疫反应改变。
收集了20例子痫前期患者和20例血压正常且妊娠无并发症的患者的血浆样本，这些血压正常的患者在年龄、孕周和产次上与子痫前期患者相匹配。样本在分娩开始、引产或医学干预之前采集。通过特异性酶联免疫测定法检测样本中的IL-12和IFN-γ。
35%的子痫前期患者检测到IL-12，而正常妊娠患者中这一比例为5%（P<0.01）。两组中IFN-γ的检测率和平均浓度相当。
子痫前期患者血浆中完整IL-12的检测更为频繁，提示该细胞因子参与了子痫前期中观察到的免疫反应增强。
