Bartram H P
Medizinischen Universitätsklinik Würzburg.
Tierarztl Prax Ausg K Kleintiere Heimtiere. 1998 May;26(3):154-9.
Helicobacter pylori plays an important role in the pathogenesis of peptic ulcer disease. Besides, epidemiological studies indicate that helicobacter may be involved in the development of gastric cancer and MALT-lymphoma by inducing gastritis and accumulation of lymph follicles in the gastric mucosa. The carcinogenic effect of helicobacter pylori can be explained by various pathogenetic factors which are produced by the bacterium itself. Furthermore, influences of helicobacter pylori on the vitamin C content of gastric mucosa might play a role. Currently, Hp-eradication therapies for the treatment of gastric MALT lymphomas are already under investigation in controlled studies. Concerning gastric cancer prevention, however, the available data are not sufficient to warrant a general recommendation for eradication-therapies of all Hp-infected persons. However, further studies must show whether Hp-eradication of high-risk subjects, i.e. members of gastric cancer families, young patients with chronic-active gastritis or with chronic-atrophic gastritis and intestinal metaplasia, are effective in reducing gastric cancer risk.
幽门螺杆菌在消化性溃疡疾病的发病机制中起重要作用。此外，流行病学研究表明，幽门螺杆菌可能通过诱发胃炎和胃黏膜淋巴滤泡积聚而参与胃癌和黏膜相关淋巴组织淋巴瘤的发生发展。幽门螺杆菌的致癌作用可由该细菌自身产生的多种致病因素来解释。此外，幽门螺杆菌对胃黏膜维生素C含量的影响可能也起一定作用。目前，针对胃黏膜相关淋巴组织淋巴瘤治疗的幽门螺杆菌根除疗法已在对照研究中进行调查。然而，关于胃癌预防，现有数据不足以支持对所有幽门螺杆菌感染者进行根除治疗的普遍建议。不过，进一步的研究必须表明，对高危人群（即胃癌家族成员、患有慢性活动性胃炎或慢性萎缩性胃炎及肠化生的年轻患者）进行幽门螺杆菌根除是否能有效降低胃癌风险。
