Grimbizis G, Camus M, Clasen K, Tournaye H, De Munck L, Devroey P
Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University, Belgium.
Hum Reprod. 1998 May;13(5):1188-93. doi: 10.1093/humrep/13.5.1188.
Fifty-seven patients who underwent hysteroscopic septum resection between January 1991 and December 1996 were studied; nine patients presented with recurrent abortions, 46 with infertility (26 primary and 20 secondary), one with dysmenorrhoea and one with an asymptomatic complete septum. Their reproductive history included 78 pregnancies: 69 (88.4%) abortions, two (2.6%) ectopics, two (2.6%) preterm deliveries and five (6.4%) term deliveries. In patients with infertility, the incidence of unexplained infertility was 19.6% and the incidence of endometriosis was 26.1%. After hysteroscopic septum resection, 42 patients were interested in pregnancy. All patients with recurrent abortions conceived spontaneously. Twenty-one (63.6%) infertile patients achieved a pregnancy, 13 (61.9%) of them after treatment with various assisted reproduction techniques. The reproductive outcome after septum resection yielded 44 pregnancies, including three sets of twins and one set of triplets reduced to twins: 11 (25%) abortions, one (2.3%) ectopic pregnancy, two (4.5%) preterm deliveries (both twins), 28 (63.7%) term deliveries and two (4.5%) as-yet ongoing pregnancies. It seems that the hysteroscopic treatment of uterine septum has a beneficial effect on pregnancy outcome. A septate uterus does not seem to be an infertility factor. The achievement of pregnancy is normal in patients with recurrent abortions, while the chances of conception in patients with infertility seem to be similar to those for the general infertile population.
对1991年1月至1996年12月间接受宫腔镜下中隔切除术的57例患者进行了研究；9例患者有反复流产史，46例有不孕问题（26例原发性不孕，20例继发性不孕），1例有痛经，1例有无症状完全中隔。她们的生育史包括78次妊娠：69次（88.4%）流产，2次（2.6%）宫外孕，2次（2.6%）早产，5次（6.4%）足月分娩。在不孕患者中，不明原因不孕的发生率为19.6%，子宫内膜异位症的发生率为26.1%。宫腔镜下中隔切除术后，42例患者有妊娠意愿。所有反复流产的患者均自然受孕。21例（63.6%）不孕患者成功妊娠，其中13例（61.9%）是在接受各种辅助生殖技术治疗后妊娠的。中隔切除术后的生殖结局为44次妊娠，包括3组双胞胎和1组三胞胎减为双胞胎：11次（25%）流产，1次（2.3%）宫外孕，2次（4.5%）早产（均为双胞胎），28次（63.7%）足月分娩，2次（4.5%）仍在妊娠中。宫腔镜治疗子宫中隔似乎对妊娠结局有有益影响。中隔子宫似乎不是不孕因素。反复流产患者的妊娠情况正常，而不孕患者的受孕几率似乎与一般不孕人群相似。
