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自行服用紧急避孕药的效果。

The effects of self-administering emergency contraception.

作者信息

Glasier A, Baird D

机构信息

Edinburgh Healthcare National Health Service Trust Family Planning and Well Woman Services, Department of Obstetrics and Gynaecology, University of Edinburgh, Scotland, United Kingdom.

出版信息

N Engl J Med. 1998 Jul 2;339(1):1-4. doi: 10.1056/NEJM199807023390101.

Abstract

BACKGROUND

Emergency postcoital contraception prevents pregnancy, but it must be prescribed by a doctor and taken within 72 hours of intercourse. It has been proposed that emergency contraception be made available without a prescription. We undertook a study to learn how women might behave if given a supply of emergency contraceptive pills to keep at home.

METHODS

We assigned 553 women to be given a replaceable supply of hormonal emergency contraceptive pills to take home (the treatment group) and 530 women to use emergency contraception obtained by visiting a doctor (the control group). The frequency of use of emergency contraception, the use of other contraceptives, and the incidence of unwanted pregnancy were determined in both groups of women one year later.

RESULTS

The results for 549 women in the treatment group and 522 women in the control group were available for analysis. Three hundred seventy-nine of the women in the treatment group (69 percent) and 326 of the women in the control group (62 percent) contributed detailed information at follow-up. One hundred eighty of the women in the treatment group (47 percent) used emergency contraception at least once. Among those who returned the study questionnaire, 98 percent used emergency contraception correctly. There were no serious adverse effects. Eighty-seven women in the control group (27 percent) used emergency contraception at least once (P<0.001 for the comparison with the treatment group). The women in the treatment group were not more likely to use emergency contraception repeatedly. Their use of other methods of contraception was no different from that of the women in the control group. There were 18 unintended pregnancies in the treatment group and 25 in the control group (relative risk, 0.7; 95 percent confidence interval, 0.4 to 1.2).

CONCLUSIONS

Making emergency contraception more easily obtainable does no harm and may reduce the rate of unwanted pregnancies.

摘要

背景

性交后紧急避孕可预防怀孕,但必须由医生开处方,并在性交后72小时内服用。有人提议应无需处方即可获得紧急避孕药。我们开展了一项研究,以了解如果给女性提供一批紧急避孕药在家备用,她们会有何行为表现。

方法

我们将553名女性分配为带回家可补充的激素紧急避孕药供应组(治疗组),530名女性分配为通过看医生获取紧急避孕药组(对照组)。一年后在两组女性中确定紧急避孕药的使用频率、其他避孕方法的使用情况以及意外怀孕的发生率。

结果

治疗组的549名女性和对照组的522名女性的结果可供分析。治疗组的379名女性(69%)和对照组的326名女性(62%)在随访时提供了详细信息。治疗组的180名女性(47%)至少使用过一次紧急避孕药。在返回研究问卷的人中,98%正确使用了紧急避孕药。未出现严重不良反应。对照组的87名女性(27%)至少使用过一次紧急避孕药(与治疗组比较,P<0.001)。治疗组的女性并非更有可能重复使用紧急避孕药。她们对其他避孕方法的使用与对照组女性无异。治疗组有18例意外怀孕,对照组有25例(相对风险,0.7;95%置信区间,0.4至1.2)。

结论

使紧急避孕药更易于获取并无危害,且可能降低意外怀孕率。

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