Badia J R, Farré R, Montserrat J M, Ballester E, Hernandez L, Rotger M, Rodriguez-Roisin R, Navajas D
Servei de Pneumologia i Al.lèrgia Respiratòria, Departament de Medicina, Hospital Clínic, Barcelona, Spain.
Eur Respir J. 1998 May;11(5):1128-34. doi: 10.1183/09031936.98.11051128.
The forced oscillation technique (FOT) is a noninvasive method of potential clinical interest for quantitatively assessing airway mechanics during sleep. We investigated the applicability of FOT as a diagnostic tool for noninvasive assessment of airflow obstruction in patients with sleep apnoea/hypopnoea syndrome (SAHS) during sleep. In seven patients previously diagnosed with severe SAHS (mean+/-SD apnoea/ hypopnoea index (AHI) 67+/-14) we performed a full polysomnography (PSG) together with on-line measurement of respiratory impedance (IZI) using FOT. For each patient we determined: 1) number of respiratory events conventionally detected by full PSG, those obtained by FOT and their degree of concordance; and 2) the characteristics and values of IZI during the respiratory events. FOT was well tolerated and easily applied in conjunction with a conventional sleep setup. The mean number of respiratory events x h(-1) detected by PSG and FOT were 55+/-16 and 58+/-17, respectively, with a strong concordance. IZI increased from a baseline of 11+/-4 to 50+/-20 cmH2O x L(-1) x s during apnoea (mean+/-SD). In all but one patient intermittent increases of IZI occurred immediately before each obstructive apnoea. In four patients, the increases of IZI developed at end-expiration whereas in two others occurred during inspiration. During hypopnoea most of the patients showed decreases of IZI during expiration. In conclusion, forced oscillation technique can be used as a noninvasive and complementary tool for the diagnosis of respiratory events and provides an on-line quantitative approach for continuous monitoring of airflow obstruction during sleep in patients with sleep apnoea/hypopnoea syndrome.
强迫振荡技术（FOT）是一种具有潜在临床应用价值的非侵入性方法，用于定量评估睡眠期间的气道力学。我们研究了FOT作为诊断工具在睡眠呼吸暂停/低通气综合征（SAHS）患者睡眠期间无创评估气流阻塞的适用性。在7例先前诊断为重度SAHS的患者中（平均±标准差呼吸暂停/低通气指数（AHI）为67±14），我们进行了全夜多导睡眠图（PSG）检查，并使用FOT在线测量呼吸阻抗（IZI）。对于每位患者，我们确定：1）全夜PSG常规检测到的呼吸事件数量、FOT获得的呼吸事件数量及其一致性程度；2）呼吸事件期间IZI的特征和数值。FOT耐受性良好，易于与传统睡眠设备联合应用。PSG和FOT检测到的每小时呼吸事件平均数量分别为55±16和58±17，两者具有很强的一致性。呼吸暂停期间，IZI从基线的11±4增加到50±20 cmH2O·L-1·s（平均±标准差）。除1例患者外，所有患者在每次阻塞性呼吸暂停前均立即出现IZI间歇性增加。4例患者在呼气末出现IZI增加，另外2例在吸气期间出现增加。在低通气期间，大多数患者在呼气时IZI降低。总之，强迫振荡技术可作为诊断呼吸事件的非侵入性补充工具，并为睡眠呼吸暂停/低通气综合征患者睡眠期间气流阻塞的连续监测提供在线定量方法。
