Liu H, Ni W, Zhao J, Xiong S, Xu Y, Zhang Z
Department of Respiratory Diseases, Tongji Hospital, Tongji Medical University, Wuhan 430030.
J Tongji Med Univ. 2000;20(4):280-2. doi: 10.1007/BF02888179.
The change of measurements of impulse oscillometry (IOS) in obstructive sleep apnea syndrome (OSAS) patients and its mechanism were observed. The respiratory impedance was measured by using IOS technique and polysomnography (PSG) was monitored synchronously in 36 OSAS patients, 14 patients with chronic obstructive pulmonary disease (COPD) and 12 normal controls. Results showed that R20 in OSAS group was significantly higher than in COPD group and control group (P < 0.01). R5-R20 in OSAS group was lower than that in COPD group, but significantly higher than that in control group (P < 0.01). The levels of R20 and R5-R20 were positively correlated with severity degree of the disease. In addition, apnea-hyponea index (AHI) was positively correlated with R5 and R20 with the correlation index (r)being 0.66 and 0.86 respectively. The lowest SO2 was negatively correlated with R5 and R5-R20, with r being -0.66 and -0.79 respectively. The mean SO2 was negatively correlated with R5 and R5-R20 with r being -0.81 and -0.69 respectively. IOS technique could be used as a valuable tool for assessing the degree of upper airway obstruction in the patients with OSAS, and could help to explore its pathological mechanism.
观察阻塞性睡眠呼吸暂停低通气综合征（OSAS）患者脉冲振荡法（IOS）测量指标的变化及其机制。采用IOS技术测量36例OSAS患者、14例慢性阻塞性肺疾病（COPD）患者及12名正常对照者的呼吸阻抗，并同步监测多导睡眠图（PSG）。结果显示，OSAS组的R20显著高于COPD组和对照组（P<0.01）。OSAS组的R5-R20低于COPD组，但显著高于对照组（P<0.01）。R20和R5-R20水平与疾病严重程度呈正相关。此外，呼吸暂停低通气指数（AHI）与R5和R20呈正相关，相关系数（r）分别为0.66和0.86。最低血氧饱和度（SO2）与R5和R5-R20呈负相关，r分别为-0.66和-0.79。平均SO2与R5和R5-R20呈负相关，r分别为-0.81和-0.69。IOS技术可作为评估OSAS患者上气道阻塞程度的有价值工具，并有助于探讨其病理机制。
