De Simone C, Guerriero C, Pellicano R
Department of Dermatology Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, 00168 Roma, Italy.
Eur J Dermatol. 1998 Jan-Feb;8(1):48-50.
Linear IgA disease is an acquired bullous disease of the skin characterized by linear IgA deposits along the dermal-epidermal junction. Inflammatory bowel diseases have been rarely reported in association with linear IgA disease. We have recently observed a patient suffering from ulcerative colitis who developed a cutaneous bullous eruption that was diagnosed as a linear IgA disease. Foreign antigens penetrating the inflamed bowel mucosa might give rise to the production of autoantibodies cross-reacting with the cutaneous antigens involved in the pathogenesis of linear IgA disease.
线状IgA疾病是一种获得性皮肤大疱性疾病，其特征是沿真皮-表皮交界处有线状IgA沉积。炎症性肠病与线状IgA疾病相关的报道很少。我们最近观察到一名患有溃疡性结肠炎的患者出现了皮肤大疱性皮疹，被诊断为线状IgA疾病。穿透发炎肠黏膜的外来抗原可能会导致产生与线状IgA疾病发病机制中涉及的皮肤抗原发生交叉反应的自身抗体。
