Westhoff C, Truman C, Kalmuss D, Cushman L, Rulin M, Heartwell S, Davidson A
College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Contraception. 1998 Apr;57(4):241-5. doi: 10.1016/s0010-7824(98)00022-5.
Women enrolled in a multicenter prospective study were evaluated to identify any possible relationship between depressive symptoms and the use of contraceptive implants. Women choosing Norplant implants (n = 910) were evaluated before starting this contraceptive and were reinterviewed at 6 months and 2 years. Women who continued the method had lower depressive symptom scores before initiating Norplant implants than did the women who discontinued the method or who were lost to follow up. Among the continuing Norplant implant users, the mean scores were similar before starting Norplant and at 6 months (7.9 vs 7.7). The strongest overall predictor of the depressive symptom score was relationship satisfaction. At 24 months, the subgroup of continuing users with decreased relationship satisfaction had an increase in depressive symptom score, but those with stable or improved relationships had stable depressive symptom scores. The subjects with the highest (i.e., worst) scores at enrollment demonstrated improved scores during follow-up. These results are reassuring for women who are concerned that Norplant use may adversely affect their mood.
对参与一项多中心前瞻性研究的女性进行了评估，以确定抑郁症状与使用避孕植入物之间是否存在任何可能的关系。选择诺普兰植入物的女性（n = 910）在开始使用这种避孕方法之前接受了评估，并在6个月和2年时再次接受访谈。继续使用该方法的女性在开始使用诺普兰植入物之前的抑郁症状评分低于停止使用该方法或失访的女性。在继续使用诺普兰植入物的使用者中，开始使用诺普兰之前和6个月时的平均评分相似（7.9对7.7）。抑郁症状评分的最强总体预测因素是关系满意度。在24个月时，关系满意度下降的继续使用者亚组的抑郁症状评分有所增加，但关系稳定或改善的使用者的抑郁症状评分保持稳定。入组时评分最高（即最差）的受试者在随访期间评分有所改善。这些结果对于担心使用诺普兰可能会对其情绪产生不利影响的女性来说是令人安心的。
