de Vries C S, van den Berg P B, de Jong-van den Berg L T
Department of Social Pharmacy and Pharmacoepidemiology, University Centre for Pharmacy, Groningen Institute for Drug Studies, State University Groningen, The Netherlands.
Contraception. 1998 Apr;57(4):247-9. doi: 10.1016/s0010-7824(98)00021-3.
In October 1995, a "pill scare" developed in Europe. In the Netherlands, the recommendations given were 1) to not alarm women without risk for deep vein thrombosis (DVT), and 2) to be reserved in prescribing third generation oral contraceptives (OC) for young women who were beginning OC use. To determine whether there is a change in the prescription of third generation OC after the latest pill scare, prescription data from 1/10/94 to 1/10/96, covering a population of +/- 120,000 persons, were studied with respect to OC use before and after the pill scare. Trend analyses revealed a significant decline in third generation compared with total OC prescribing only in the youngest age category (p = 0.0034). Further, switch behavior was studied. Switches from third to second generation OC were more prevalent after the pill scare than before (odds ratio = 2.63; 95% confidence interval 1.84-3.75) and switches from second to third generation OC were significantly less prevalent after the pill scare. This indicates that Dutch prescribers have reacted to the pill scare in the way that the government recommended.
1995年10月，欧洲出现了一场“避孕药恐慌”。在荷兰，给出的建议是：1）不要惊吓没有深静脉血栓形成（DVT）风险的女性；2）对于开始使用口服避孕药（OC）的年轻女性，在开具第三代口服避孕药时要谨慎。为了确定在最近这场避孕药恐慌之后第三代口服避孕药的处方是否有变化，研究了1994年10月1日至1996年10月1日涵盖约12万人的处方数据，涉及避孕药恐慌前后的口服避孕药使用情况。趋势分析显示，仅在最年轻年龄组中，与口服避孕药总处方量相比，第三代口服避孕药的处方量显著下降（p = 0.0034）。此外，还研究了换药行为。避孕药恐慌之后，从第三代口服避孕药换为第二代口服避孕药的情况比之前更普遍（优势比 = 2.63；95%置信区间1.84 - 3.75），而从第二代口服避孕药换为第三代口服避孕药的情况在避孕药恐慌之后显著减少。这表明荷兰的处方医生已按照政府建议对避孕药恐慌做出了反应。
