Absorption, tissue distribution and excretion of 14C ethylenethiourea by the rhesus monkey and rat.

Two female rhesus monkeys and four Sprague-Dawley rats were give 14C ethylenethiourea by gastric intubation and the rate of excretion was evaluated for 48 hours. The animals were subsequently sacrificed and the tissue distribution of 14C determined. The major route of 14C excretion was by way of the urine with 47 and 64% of the total radioactivity in the monkey urine and an average of 82% in the rat urine. The feces accounted for less than 1.5% of the radioactivity in both animal species. Tissue distribution accounted for 21 and 28% of the administered 14C in the monkey, while less than 1% was located in the rat tissues. The skin and musculature contained the largest amount of radioactivity in both species.