Faxon D P, Borst C
Division of Cardiology, University of Southern California 90033, USA. dfaxon hsc.usc.edu
Semin Interv Cardiol. 1997 Sep;2(3):145-6.
The changes that occur in both the structure and geometry of blood vessels in pathological conditions has been termed remodelling. The importance of the changes in geometry have only been recently widely appreciated, although geometric remodelling has been recognized for more than 30 years. Geometric remodelling can be favourable, as occurs with compensatory enlargement, or unfavourable, as with constriction. Vascular remodelling is recognized to occur in a variety of pathological conditions, including atherosclerosis, hypertension, arterio-venous grafts, and following restenosis. A better understanding of the pathophysiology should permit development of new therapeutic strategies to treat these conditions.
在病理状态下血管结构和几何形状发生的变化被称为重塑。尽管几何重塑已被认识超过30年，但几何形状变化的重要性直到最近才得到广泛认可。几何重塑可能是有利的，如代偿性扩张时出现的情况，也可能是不利的，如血管收缩时的情况。血管重塑被认为发生在多种病理状态中，包括动脉粥样硬化、高血压、动静脉移植以及再狭窄后。对病理生理学的更好理解应该有助于开发治疗这些病症的新治疗策略。
