2型和4型腺病毒在人淋巴细胞培养物中的复制比较。
Comparison of replication of adenovirus type 2 and type 4 in human lymphocyte cultures.
作者信息
Lambriex M, Van der Veen J
出版信息
Infect Immun. 1976 Sep;14(3):618-22. doi: 10.1128/iai.14.3.618-622.1976.
Abstract
Adenovirus type 2 was capable of replicating in purified lymphocyte cultures from human adenoid specimens. Phytohemagglutinin stimulation enhanced the replication of virus. Viral titers of 103 to 104 50% tissue culture infective doses per ml were reached after 4 to 8 days. Only 1 to 3 per 106 cells were found to produce virus. In contrast, there was no evidence that lymphocyte cultures could support the replication of adenovirus type 4. The life span of cultures infected with type 2 or 4 was not reduced. The possibility that lymphocytes infected with virus play a role in initiating natural, persisting adenovirus infections of human adenoids is discussed.
摘要
2型腺病毒能够在来自人腺样体标本的纯化淋巴细胞培养物中复制。植物血凝素刺激可增强病毒的复制。4至8天后，病毒滴度达到每毫升10³至10⁴个50%组织培养感染剂量。每10⁶个细胞中仅发现1至3个产生病毒。相比之下，没有证据表明淋巴细胞培养物能够支持4型腺病毒的复制。感染2型或4型病毒的培养物的寿命没有缩短。本文讨论了感染病毒的淋巴细胞在引发人腺样体自然持续性腺病毒感染中发挥作用的可能性。
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