Ekdahl K, Hansson H B, Mölstad S, Söderström M, Walder M, Persson K
Regional Centre of Communicable Disease Control, Malmö, Sweden.
Microb Drug Resist. 1998 Summer;4(2):99-105. doi: 10.1089/mdr.1998.4.99.
In an attempt to limit the spread of penicillin-resistant pneumococci (PRP), an intervention project was initiated in the Malmöhus County, southern Sweden in January 1995. The ongoing project combines traditional communicable disease control measures and actions aiming at reducing antibiotics consumption. All patients in the county with a nasopharyngeal culture positive for PRP with MIC of Penicillin G > or =0.5 mg/L are followed with nasopharyngeal cultures until PRP-negative. Nasopharyngeal cultures are obtained from family members and close contacts of the index cases. Preschool children carrying PRP are denied attendance at group day-care. From January 1995 to March 1997, 1,038 PRP-carriers (429 index cases and 609 contact cases) were identified. Children aged 1-6 years dominated (83%). Antibiotics sales decreased during the study period, and epidemiologic data indicate that the intervention may have limited the dissemination of PRP in the county, but further evaluation is needed.
为了限制耐青霉素肺炎球菌（PRP）的传播，1995年1月在瑞典南部的马尔默胡斯县启动了一个干预项目。正在进行的项目结合了传统的传染病控制措施以及旨在减少抗生素使用的行动。该县所有鼻咽培养物中PRP呈阳性且青霉素G的最低抑菌浓度（MIC）≥0.5mg/L的患者，都要进行鼻咽培养随访，直至PRP呈阴性。从病例的家庭成员和密切接触者中获取鼻咽培养物。携带PRP的学龄前儿童被禁止参加集体日托。1995年1月至1997年3月，共识别出1038名PRP携带者（429例索引病例和609例接触病例）。1至6岁的儿童占主导（83%）。在研究期间抗生素销量下降，流行病学数据表明该干预措施可能限制了PRP在该县的传播，但仍需进一步评估。
