Laboratory of Quality Control, Bromatology & Microbiology, Department of Biological & Health Sciences, School of Pharmacy, Federal University of Amapá, Rodovia Juscelino Kubitscheck, km 02, Macapá 68903-419, Brazil.
Department of Surfactants and Nanobiotechnology, Instituto de Química Avanzada de Cataluña, Centro Superior de Investigaciones Científicas IQAC-CSIC, 08035 Barcelona, Spain.
Molecules. 2023 Sep 11;28(18):6570. doi: 10.3390/molecules28186570.
The antimicrobial and antibiofilm properties of arginine-based surfactants have been evaluated. These two biological properties depend on both the alkyl chain length and the spacer chain nature. These gemini surfactants exhibit good activity against a wide range of bacteria, including some problematic resistant microorganisms such us methicillin-resistant (MRSA) and . Moreover, surfactants with a C alkyl chain and C spacer inhibit the (MRSA) and biofilm formation at concentrations as low as 8 µg/mL and are able to eradicate established biofilms of these two bacteria at 32 µg/mL. The inhibitory activities of the surfactants over key enzymes enrolled in the skin repairing processes (collagenase, elastase and hyaluronidase) were evaluated. They exhibited moderate anti-collagenase activity while the activity of hyaluronidase was boosted by the presence of these surfactants. These biological properties render these gemini arginine-based surfactants as perfect promising candidates for pharmaceutical and biological properties.
已评估基于精氨酸的表面活性剂的抗菌和抗生物膜特性。这两种生物学特性既取决于烷基链长度，也取决于间隔基链性质。这些双子表面活性剂对包括一些有问题的耐药微生物（如耐甲氧西林金黄色葡萄球菌（MRSA）和 ）在内的多种细菌具有良好的活性。此外，具有 C 烷基链和 C 间隔基的表面活性剂在低至 8 µg/mL 的浓度下即可抑制（MRSA）和 的生物膜形成，并能在 32 µg/mL 时清除这两种细菌的已建立的生物膜。评估了这些表面活性剂对参与皮肤修复过程的关键酶（胶原酶、弹性蛋白酶和透明质酸酶）的抑制活性。它们表现出适度的抗胶原酶活性，而透明质酸酶的活性则因这些表面活性剂的存在而增强。这些生物学特性使这些双子精氨酸基表面活性剂成为药物和生物学特性的理想候选物。
