蛋白酶体组装：自食其果。

Proteasome assembly: biting the hand.

作者信息

Maurizi M R

机构信息

Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.

出版信息

Curr Biol. 1998 Jun 18;8(13):R453-6. doi: 10.1016/s0960-9822(98)70291-x.

DOI:10.1016/s0960-9822(98)70291-x

PMID:9651672

Abstract

Proteasome assembly is regulated to ensure the enzyme is inactive until its active sites are compartmentalized within an interior aqueous chamber. In yeast, this depends on a dedicated chaperone that is trapped within the nascent proteasome, and degraded on maturation of the proteolytic subunits.

摘要

蛋白酶体的组装受到调控，以确保该酶在其活性位点被分隔在内部水相腔室中之前保持无活性。在酵母中，这依赖于一种专门的伴侣蛋白，它被困在新生的蛋白酶体中，并在蛋白水解亚基成熟时被降解。