Apolone G, Filiberti A, Cifani S, Ruggiata R, Mosconi P
Laboratorio per la Ricerca Clinica Oncologica, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Ann Oncol. 1998 May;9(5):549-57. doi: 10.1023/a:1008264412398.
Despite the large amount of data available about the EORTC QLQ-C30 questionnaire, there have been very few studies focussed on long-survival cancer patients, and no data are available on its performance in the Italian setting.
Within the framework of a project aimed at evaluating the characteristics of available HR-QOL questionnaires in the Italian language, the EORTC QLQ-C30 questionnaire together with the Short Form 36-item Health Survey (SF-36) were mail-administered to a sample of patients previously recruited in two large multicenter randomized clinical trials on early breast and colon cancers. The properties of the questionnaire were evaluated using standard psychometric techniques and correlation analyses with demographic and clinical independent variables.
In the sample of patients who sent back the questionnaires under evaluation, the EORTC QLQ-C30 showed satisfactory acceptability (response rate = 64% and very low prevalence of missing at item and scale level), and the psychometric analyses confirmed the multi-dimensional conceptualisation in terms of convergent and discriminant validity. Moreover, EORTC QLQ-C30 scales showed substantial correlation with the homologous SF-36 scales. Few socio-demographic (age, gender, schooling) and clinical (type of cancer disease) variables were associated with HR-QOL. Breast cancer patients reported, on average, worse physical health-related scores, but after adjustment for age and education, most of the differences disappeared.
These findings confirm the validity and robustness of the EORTC QLQ-C30 in this sample of long-survival Italian cancer patients. Further ad hoc validation studies are required to evaluate its significance in these particular patients.
尽管有大量关于欧洲癌症研究与治疗组织核心生活质量问卷（EORTC QLQ-C30）的数据，但针对长期存活癌症患者的研究极少，且尚无其在意大利环境下表现的数据。
在一个旨在评估意大利语可用健康相关生活质量问卷特征的项目框架内，将EORTC QLQ-C30问卷与简短健康调查问卷（SF-36）邮寄给先前在两项关于早期乳腺癌和结肠癌的大型多中心随机临床试验中招募的患者样本。使用标准心理测量技术以及与人口统计学和临床独立变量的相关分析来评估问卷的属性。
在回复所评估问卷的患者样本中，EORTC QLQ-C30显示出令人满意的可接受性（回复率 = 64%，项目和量表层面的缺失率极低），并且心理测量分析从收敛效度和区分效度方面证实了其多维概念化。此外，EORTC QLQ-C30量表与同源的SF-36量表显示出显著相关性。很少有社会人口统计学（年龄、性别、受教育程度）和临床（癌症疾病类型）变量与健康相关生活质量相关。乳腺癌患者平均报告的与身体健康相关的得分较差，但在对年龄和教育程度进行调整后，大多数差异消失。
这些发现证实了EORTC QLQ-C30在这个长期存活的意大利癌症患者样本中的有效性和稳健性。需要进一步的专项验证研究来评估其在这些特定患者中的意义。
