Akbari H, D'Emanuele A, Attwood D
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, United Kingdom.
Pharm Dev Technol. 1998 May;3(2):251-9. doi: 10.3109/10837459809028502.
The aim of this study was to investigate the effect of device fabrication technique on the erosion characteristics of poly[1,3-bis(p-carboxyphenoxy) propane:sebacic acid] [p(CPP:SA)] 20:80 copolymer. Devices were prepared using melt-molding, solvent-casting, and compression-molding techniques and their erosion was followed by determining changes in device morphology, molecular weight, water uptake, mass loss, and release of monomers, with time of immersion in phosphate buffer pH 7.4 at 37 degrees C. Melt-molded devices had a very dense and uniform structure and displayed characteristics typical of surface eroding systems. Devices produced using a solvent-casting technique had a very porous structure with no detectable erosion zone and the erosion profiles were indicative of bulk rather than pure surface erosion. Compression-molded devices had a dense structure and revealed a faster rate of erosion than melt-molded devices. A comparison of the extent of changes of polymer molecular weight, water uptake, mass loss, and monomer release showed a marked dependence on the method of fabrication.
本研究的目的是调查器件制造技术对聚[1,3-双（对羧基苯氧基）丙烷：癸二酸][p（CPP:SA）]20:80共聚物侵蚀特性的影响。使用熔融成型、溶剂浇铸和压缩成型技术制备器件，并通过测定器件形态、分子量、吸水率、质量损失和单体释放随在37℃pH 7.4磷酸盐缓冲液中浸泡时间的变化来跟踪其侵蚀情况。熔融成型的器件具有非常致密且均匀的结构，并表现出表面侵蚀系统的典型特征。使用溶剂浇铸技术生产的器件具有非常多孔的结构，没有可检测到的侵蚀区，侵蚀曲线表明是本体侵蚀而非单纯的表面侵蚀。压缩成型的器件具有致密的结构，并且显示出比熔融成型的器件更快的侵蚀速率。对聚合物分子量、吸水率、质量损失和单体释放变化程度的比较表明，其明显依赖于制造方法。
